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we report the 3.3-mb draft genome of laceyella sacchari strain gs 1 - 1 , isolated from hot spring water sample , chumathang , leh , india . draft genome of strain gs 1 - 1 consists of 3 , 324 , 316 bp with a g + c content of 48.8% and 3429 predicted protein coding genes and 75 rnas . geobacillus thermodenitrific... | 2005 after a detailed polyphasic study and reclassification on the genus thermoactinomyces . at present the genus laceyella has four recognized species namely ; laceyella putida , l. sacchari , type species of the genus laceyella , laceyella sediminis and laceyella tengchongensis . cells are aerobic , non - ... |
a convenient method for chemically treating zebrafish is to introduce the reagent into the tank water , where it will be taken up by the fish . however , this method makes it difficult to know how much reagent is absorbed or taken up per fish . some experimental questions , particularly those related to metabolic ... | the basic fasting protocol is to transfer the fish , at their normal density , to a clean tank , then withhold food . for longer - term fasting that requires more rigorous conditions ( e.g. , for blood glucose studies ) , see additional considerations in the discussion . for a 100 ml volume , dissolve the following i... |
post - herpetic neuralgia ( phn ) is neuropathic pain persisting after an acute episode of herpes zoster , and is associated with severe pain and sensory abnormalities that adversely affect the patient s quality of life and increase health care costs . up to 83% of patients with phn describe localized neuropathic pa... | neuropathic pain , defined as pain arising as a direct consequence of a lesion or a disease affecting the somatosensory system,1 is a disorder that can considerably affect quality of life for patients . even though up to 5% of the general population could be involved , treatment of neuropathic pain continues to be cha... |
the occurrence of nephrotic syndrome following a bee sting is rarely reported in the literature . hypersensitivity is believed to be the precipitating factor for the renal disease . we report a two - year - old boy , who developed generalized edema and decreased urine output , seven days after a bee sting . physic... | nephrotic syndrome ( ns ) in children is usually idiopathic , but may also be triggered by immunological stimuli like vaccination , infection , insect sting , or pollen hypersensitivity . humoral and cellular immune function studies suggest that abnormal immune response is the probable cause in this clinical entity . b... |
parents frequently bring their children to general or pediatric emergency departments ( eds ) , even though many of these visits are judged by others to be nonurgent and inappropriate . this study examined the motives behind parents ' decisions to take their children to a pediatric emergency department ( ped ) . a... | emergency department ( ed ) use is common for both children and adults not only in a country without universal health insurance like the united states but also in countries like france where virtually all residents have health insurance . in 2006 the annual rate of ed visits for parisian children less than 2 years ol... |
we investigated in a sample of latinos the practices of antimicrobial drug importation and use of nonprescribed antimicrobial drugs . in interviews conducted with 219 adults , we assessed health beliefs and past and present behaviors consistent with acquiring antimicrobial drugs without a prescription in the united st... | south carolina , like many other cities and states that have historically had few latinos , has experienced recent surges in immigration and now has small informal enclaves and social structures . many latinos in these new communities may lack documentation for us residency . consequently , our sampling design took int... |
common genetic variations in the gene encoding transcription factor 7-like 2 ( tcf7l2 ) reveal the strongest association with type 2-diabetes known to date . these lead to impaired insulin production and output , but the mechanisms of disease remain incompletely known . in this issue of diabetologia , two publicat... | the author receives funding from the swedish research council , the ragnar sderbergs stiftelse , the novonordisk foundation and lund university . the author is also part of the following strategic research consortia in diabetes : the linnaeus lund university diabetes center ( ludc ) funded by the swedish research counc... |
photodynamic therapy ( pdt ) has been used for treatment of various intraocular tumors including choroidal hemangioma , vasoproliferative tumor , amelanotic choroidal melanoma and choroidal neovascular membrane due to choroidal osteoma . this case report documents the effect of pdt for a presumed acquired retinal as... | acquired retinal astrocytoma is a benign glial intraretinal tumor.1 it is considered the retinal equivalent of low - grade brain astrocytomas . despite its benign cytology , it can show progressive growth and behave as a locally aggressive malignant tumor . the clinical course can be complicated with exudative retinal ... |
we report a very rare case of hemangioblastomatosis that developed after surgical removal of a solitary cerebellar hemangioblastoma ( hb ) . a 51-yr - old man presented with back pain 10 yr after undergoing surgery for cerebellar hb . magnetic resonance imaging showed numerous mass lesions along the entire neuraxis ... | hemangioblastoma ( hb ) of the central nervous system is a benign neoplasm of the central nervous system that usually involves the brain and spinal cord . it may occur sporadically or in association with von hippel - lindau ( vhl ) disease ( 1 - 5 ) . in sporadic , non - vhl cases , the tumors are usually solitary , an... |
monogenic autoinflammatory syndromes ( maiss ) are caused by innate immune system dysregulation leading to aberrant inflammasome activation and episodes of fever and involvement of skin , serous membranes , eyes , joints , gastrointestinal tract , and nervous system , predominantly with a childhood onset . to date ,... | in the recent years , the identification of genes involved in the modulation of inflammatory and apoptotic processes and the improved understanding of mechanisms linked to the aberrant activation of the inflammasome , amultiprotein intracytoplasmatic scaffold complex synthesizing the biologically active interleukin- ( ... |
weight gain is a common sequela of suprasellar tumors , referred to as hypothalamic obesity . we undertook an evaluation of obesity and metabolic aberrations among patients treated at our institute . during the 12 mo from apr . 2005 , 23 patients ( 10 males and 13 females ) with remitted suprasellar tumors... | brain tumors located in the suprasellar region are frequently found in childhood , and include craniopharyngioma , germinoma , optic nerve glioma and histiocytosis ( 1 ) . following the extension of the tumor or intervening procedures , such as surgery , chemotherapy and radiation , considerable damage to the hyp... |
in the present study , the authors investigated the management of mechanical valve thrombosis ( mvt ) . from january 1981 through march 2006 , 2,908 mechanical valve replacements were performed in 2,298 patients at our institution . twenty ( 0.87% ) patients presented with mvt , 14 ( 70.0% ) were women , and the mean ... | mechanical valve thrombosis ( mvt ) may cause valve dysfunction , and its onset may be acute or gradual , according to the nature of thrombi ( rapid or slow growth ) and involvement of hinge point ( abrupt or insidious ) . edmunds defined mechanical valve thrombosis as a complication attributable to any type of thrombu... |
primary squamous cell carcinoma of the thyroid is an extremely rare neoplasm with aggressive behavior . until date , only around 60 cases have been reported in the literature . primary treatment of the patient is radical surgery . with optimum treatment survival is not more than 6 months in this aggressive maligna... | squamous cell carcinoma ( scc ) of the thyroid is an extremely rare disease accounting for less than 1% of all thyroid tumors . in the world health organization classification , squamous cell carcinoma thyroid is defined as scc of the thyroid should be composed entirely of tumor cells with squamous differentiation . ... |
the aim of this article is to provide a short review of the most relevant pharmacological and clinical data on pramipexole extended release ( er ) as well as to address the clinical utility and potential advantages of a once - daily formulation especially in the treatment of early parkinson s disease ( pd ) . pramip... | although levodopa ( ld ) still remains the gold standard for symptomatic efficacy in reducing the motor symptoms of parkinson s disease ( pd),1 its long - term use is associated with the development of potentially disabling motor complications , including response oscillations as well as drug - induced dyskinesias ( ld... |
concentrations of glutarate ( ga ) and its derivatives such as 3-hydroxyglutarate ( 3ohga ) , d- ( d-2ohga ) and l-2-hydroxyglutarate ( l-2ohga ) are increased in plasma , cerebrospinal fluid ( csf ) and urine of patients suffering from different forms of organic acidurias . it has been proposed that these derivativ... | glutaric aciduria type i is caused by deficiency of the enzyme glutaryl coa - dehydrogenase ( gcdh ) in the metabolic pathway of lysine , hydroxylysine , and tryptophan , leading to an accumulation of glutaric acid ( ga ) and its derivative 3-hydroxy glutaric acid ( 3ohga ) ( funk et al . 2005 ; harting et al . 2-hydox... |
fibromyalgia is a chronic pain syndrome characterized by widespread pain , fatigue , and memory and mood disturbances . despite advances in our understanding of the underlying pathophysiology , treatment is often challenging . new research indicates that changes in functional connectivity between brain regions , a... | fibromyalgia is a chronic pain syndrome of unknown origin , estimated to affect 25% in all populations studied ( raspe , 1992 ; wolfe et al . , 1995 ; fibromyalgia is characterized by widespread pain , fatigue , poor sleep , and dyscognition ( wolfe et al . , 2010 ) and is often also associated with mood disorders such... |
introductioncolonic metastases are rare , and usually secondary from malignant tumours of the stomach , breast , ovarian , cervix , kidney , lung , prostate , or skin . around one third are asymptomatic or found only at autopsy.case reporta middle - aged male smoker , who had a small cell carcinoma of the lung diagn... | several malignant tumours can metastasize to the colon , including those of the stomach , breast , ovary , cervix , kidney , lung , prostate and skin . clinical symptoms and signs may suggest the diagnosis , but one third of such patients are asymptomatic and the diagnosis may be an incidental finding at autopsy . ther... |
to evaluate the sealing capability of external hexagon implant systems and assess the marginal fit , two groups ( n = 10 each ) were employed : sin ( sistema de implantes nacional , brazil ) and osseotite , ( biomet 3i , usa ) . sealing capability was determined by placing 0.7 l of 1% acid - red solution in the imp... | the use of dental implants has revolutionized prosthodontics and the fixed treatment options that can be offered to patients . high survival rates and long - term predictability for clinically loaded endosseous implants have been consistently reported resulting in one of the most successful treatment modalities in dent... |
the aim of this longitudinal study is to present data from 76 female patients treated with bisphosphonates ( bps ) for postmenopausal osteoporosis and referred to the unit of oral diagnosis and day surgery of the university of milano for diagnosis and treatment . all patients received a thorough oral examination .... | postmenopausal osteoporosis is a systemic skeletal condition that affects many millions of women around the world . the national institutes of health consensus conference defined osteoporosis as a disease of increased skeletal fragility accompanied by microarchitectural deterioration and low bone mineral density ( a t ... |
long - distance trafficking of membranous structures along the cytoskeleton is crucial for secretion and endocytosis in eukaryotes . molecular motors are transporting both secretory and endocytic vesicles along polarized microtubules . here , we review the transport mechanism and biological function of a distinct ... | eukaryotic cells depend on vesicle - mediated endocytosis and secretion to interact and communicate with their environment . such membrane - based cellular processes are dynamic as well as closely interconnected and thus require complex cellular logistics . small vesicles , for example , cycle between the endoplasmic r... |
aims and objectives : to study the stress concentrations in endodontically treated maxillary central incisor teeth restored with 3 different fiber post systems subjected to various oblique occlusal loads.materials and methods : fem analysis was used to analyze stress concentrations generated in maxillary anterior teet... | as regards the selection criteria of the post system , clinicians often succumb to marketing tactics as opposed to clinical evidence . this study attempts to bridge this gap by using finite element analysis model to analyze the effect of oblique loading forces and their stress concentration in the entire assembly when ... |
abstractbackgroundthe objective of this study was to assess the knowledge and views of faculty members on criteria for authorship by international committee of medical journal editors ( icmje ) , their current practice of choosing the authors , views on gift authorship and problems they had faced concerning authorship... | in most of the peer review publications in the late 17 century , authorship of papers generally used to be autonomous and was attributed to the sponsors ( 1 ) . however , now the readers wish to know who paid for research and who did the work . problems with authorship persist everywhere despite the international commi... |
background : patients with pulmonary arterial hypertension ( pah ) associated with systemic sclerosis ( ssc - apah ) experience higher mortality rates than patients with idiopathic disease and those with other connective tissue diseases ( ctd - apah ) . we sought to identify unique predictors of mortality associated... | the reveal registry is a longitudinal registry involving 54 pulmonary hypertension centers in the united states ( e - appendix 1 ) . diagnosis was defined as the date of diagnostic right - sided heart catheterization ( rhc ) occurring at or before the date of enrollment . patients with new diagnoses were defined as t... |
objective . to determine if gait waveform could discriminate children with diplegic cerebral palsy of the gmfcs levels i and ii . patients . twenty - two children with diplegia , 11 classified as level i and 11 as level ii of the gmfcs , aged 7 to 12 years . methods . gait kinematics included angular displ... | cerebral palsy is a nonprogressive central nervous system disorder that results in physical impairments and functional limitations that change as the children grow older . among a large number of instruments [ 24 ] , for measuring the physical ability of children with cp , the gross motor function classification system... |
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