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|---|---|---|---|---|---|---|---|
gen_61c1aeef76ee004f344db1ea77ce7cc7
|
Infection Innovation Consortium (iiCON)
|
UK Research and Innovation
|
Liverpool School of Tropical Medicine
|
HRCS22_22418
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_4f8a36782438b7273d4dcedf3505e89d
|
London Advanced Therapies
|
Research England
|
King's College London
|
HRCS22_22419
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_e9f3576e6092a84cd476c80f85549ad4
|
UK SPINE KE: free flow of knowledge to accelerate innovations in ageing
|
Research England
|
University of Oxford
|
HRCS22_22420
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_0c4560c1f7206d8946fc6b1b5a053cd3
|
SETsquared scale-up programme
|
Research England
|
University of Bath
|
HRCS22_22421
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_a43ec44cb6eac411dbc6693111ea803e
|
The Bloomsbury SET: Connecting Capability to Combat the Threat from Infectious Disease and Antimicrobial Resistance
|
Research England
|
Royal Veterinary College
|
HRCS22_22422
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_bde24fc0b161cb70a9b23814b0f9ea7e
|
MedTech SuperConnector
|
Research England
|
Imperial College London
|
HRCS22_22423
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_91509e2819b98b13cb3d70c5a7c4faf7
|
Aetiological insights
|
Research England
|
University of Exeter
|
HRCS22_22424
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_e78315bca945784c02dbeaefc51ae8af
|
Creative Destruction Lab - Oxford
|
Research England
|
University of Oxford
|
HRCS22_22425
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_4ab9088e36a4da2682f06bd2c8837ae0
|
Design Age Institute
|
Research England
|
Royal College of Art
|
HRCS22_22426
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_58694b072f36edfef2da55f1a868da2a
|
Insights North East (INE)
|
Research England
|
Newcastle University
|
HRCS22_22427
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_57894f858b6f2930cc28e19a3f592e88
|
Developing a model of Student-led Knowledge Exchange (SLKE) using Transformative Evaluation
|
Research England
|
University of St Mark and St John (Plymouth Marjon University)
|
HRCS22_22428
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_844e16f6fb4eae072cb35f6e89941bee
|
Innovating Knowledge Exchange: Student Involvement in Delivering Better Patient Experience in the NHS
|
Research England
|
The Royal Central School of Speech and Drama
|
HRCS22_22429
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_b6fd20c8b73a99950d03002d2eaa24b4
|
Tackling the Blues
|
Research England
|
Edge Hill University
|
HRCS22_22430
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_cd94a877649e992c440a6907bf114a35
|
Evaluating Converge: placing students and education at the heart of improving community mental health
|
Research England
|
York St John University
|
HRCS22_22431
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_411f115af0007c9eb4c5f4850057399f
|
Towards Net Zero Medicines Development & Manufacturing
|
Research England
|
University of Strathclyde
|
HRCS22_22432
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_a5aacf748adfc887e331f6109355453b
|
The London Institute of healthcare engineering
|
Research England
|
King's College London
|
HRCS22_22433
|
Not available
|
Infrastructure
| 7research_infrastructure
|
gen_d4fd0ae098e1fef6a0dfc98b56b12a61
|
Gates Foundatoin
|
Texas Higher Education Foundation
|
INV-031917
|
to support the implementation of a modern flexible data architecture at the Coordinating Board that delivers user-centered value through dynamic access, robust governance and security
|
Discovery and Translational Sciences / U.S. Program
| 7research_infrastructure
|
|
gen_9bdf3b80fd9f4b762792c4c96fdfb1be
|
Tycho Brahes forfatterskab digitalt formidlet
|
Carlsberg Foundation
|
Det Danske Sprog- og Litteraturselskab
|
CF18-0320
|
Not available
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_2807bac4f3907ad09bb074e02b553a4f
|
Disentangling microbial sources of nitrous oxide through dual isotope tracing and multicollector isotope ratio mass spectrometry
|
Carlsberg Foundation
|
University of Southern Denmark
|
CF18-1071
|
Not available
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_8ecc04427e3b3dc268c1b2af6d47dd2f
|
Innovative tools for decrypting a 1 million years old ice core from East Antarctica
|
Carlsberg Foundation
|
University of Copenhagen
|
CF21-0199
|
The ice from the upcoming "Beyond EPICA Oldest Ice" project requires novel methods to resolve the very compressed climate signal in the ice layers in the deepest and oldest ice. We apply for funding for acquiring laboratory equipment necessary to develop two novel techniques for advanced ice core analysis that will allow the interpretation of the 1.5 million-year-old ice expected in this ice core drilled in East Antarctica. Through the Horizon2020 ITN program DEEPICE we have secured funding for two PhD students who will work on the development and application of the two new measurement techniques.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_6a418c50adb96c45d7067fedc17327a7
|
Chemical and Toxicological Fingerprinting Infrastructure (Contaminomics)
|
Novo Nordisk Foundation
|
University of Copenhagen
|
NNF22OC0075387
|
There is growing scientific evidence that unexpected, unmonitored and unregulated contaminants are present in the environment. Despite public concern, risk assessment continues to be based on a limited number of chemicals, although hundreds of thousands of chemicals are produced and sold in Europe every year. The challenge is particularly evident when only a small fraction of the measured toxicity of an environmental sample can be explained by currently monitored chemicals. The proposed infrastructure will enable us to measure chemical and ecotoxicological fingerprints concurrently. By measuring the chemical composition and the bioactivity of a complex sample in the same workflow and through consistent, coherent data analysis workflows we will build data libraries and competences that can significantly accelerate the identification of unknown bioactive compounds in environmental samples.
|
Research Infrastructure / Infrastructure / Award
| 7research_infrastructure
|
gen_b11364e3c642045f68fe7e55f6cf75bb
|
Danmarks Kirker
|
Carlsberg Foundation
|
Nationalmuseet
|
CF23-1014
|
Danmarks Kirker er Nationalmuseets grundlæggende beskrivelse af de danske kirker. Formålet er at udforske og udbrede kendskabet til kirkebygningerne, deres kalkmalerier, inventar og gravminder. Værket dokumenterer en central del af den danske kulturarv og yder et vigtigt bidrag til kirkernes beskyttelse og bevaring. Beskrivelserne udgives som bøger og er også frit tilgængelige som pdf'er online.What? Why? How?
|
Research / Publication / Award
| 7research_infrastructure
|
gen_4fbb0fcb907762d3ae2e2cc807d045bc
|
Strengthening public and scientific outreach activities at the Danish National Biobank (DNB)
|
Novo Nordisk Foundation
|
Danmarks Nationale Biobank
|
NNF18SA0035334
|
Not available
|
Research / Infrastructure / Award
| 7research_infrastructure
|
gen_3627fa0a7e97417eceec2c26e896f586
|
Seeing is believing: 3D Chemical Imaging using Raman Microscopy
|
Carlsberg Foundation
|
University of Copenhagen
|
CF19-0521
|
Not available
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_fe9df12bff1a5510a0fcf30769e4bd67
|
Physiological amino acid analyzer for protein and peptide quantification.
|
Carlsberg Foundation
|
Aarhus University
|
CF19-0120
|
Accurate quantitation is essential to protein studies in a multitude of research topicsboth in industry and in the research laboratory. Traditional dye-based absorbance measurement or direct ultraviolet absorbance at 280 nm are most often used. However, these methods have several disadvantages. The dye-based assays use reagents that are prone to interference from chemicals prevalent in many biological buffers and impurities in the samples that may absorb UV light and thwart the measurements. Amino acid analysis is the reference method for protein quantification and is essential because protein quantification is critical as the outcome of any process involving proteins depend on the protein concentration. What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_e54a9ad319c99f3ef6dc84ad52d58c3e
|
DESIRE: Data Science Research Infrastructure In Radiotherapy
|
Novo Nordisk Foundation
|
University of Aarhus
|
NNF22OC0077893
|
Radiotherapy is relevant for 50% of all cancer patients. The wealth of information that is available in the medical images in radiotherapy has until now only been sparsely used and not been quantified in a way useable for data science. The Data Science Infrastructure in Radiotherapy (DESIRE) project will enable overview and collection of all images, dose plans and other relevant information from all Danish radiotherapy departments. This will provide a unique platform for data science in radiation oncology, at a level unsurpassed internationally due to the highly standardized and homogeneous guidelines for protocols and treatment in Denmark. Danish data scientists will be able to use complete and curated data for data mining, deep learning and AI-based automation, including segmentation, dose planning, quality assurance and model-based prediction of outcome. Cancer treatment will be improved and DESIRE will stand as the foundation of internationally recognized data science research.
|
Research Infrastructure / Infrastructure / Award
| 7research_infrastructure
|
gen_acaa20e2045aaf97e0516d5fa76be3c2
|
Mapping the genetic variations behind exercise intolerance and serious muscle damage
|
Carlsberg Foundation
|
Statens Serum Institut
|
CF19-0733
|
Not available
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_f69d1724d43062c329c1b580752ae2bb
|
Infrastructure for Center for Corporate Governance
|
Carlsberg Foundation
|
Copenhagen Business School
|
CF23-1476
|
The aim of this project is to improve and update the research facilities of Center for Corporate Governance. These are essential for the possibilities for the researchers at the center to enhance the depth and breath of our contributions to the fields of finance and sociology, and potentially inform policy and corporate governance practices.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_af3a38134d8f1b1c251e1e6260b6e52e
|
An 80 MHz benchtop NMR spectrometer for flow chemistry applications
|
Carlsberg Foundation
|
Technical University of Denmark
|
CF20-0299
|
Chemistry and enzymatic reactions are often performed in batches for a certain time. It is beneficial instead to perform reactions in a flow reactor. A powerful analysis method to elucidate the outcome of reactions is NMR spectroscopy, where the sample is placed in a strong magnetic field and irradiated with radio frequency signals. The project will develop NMR methods on a small NMR instrument, which can monitor the reactions in real time by passing output of a flow reactions directly into the instrument. The project aims to elucidiate and optimize both enzymatic conversion of polysaccharides and a variety of chemical transformations. The improved reactions will be of significant importance for application in medicinal chemistry and better utilization of renewable resources.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_6d0a5b16e5fe15e81b9e9ee0ae084451
|
Microprofiler to map aquaculture biofilm functions
|
Carlsberg Foundation
|
Technical University of Denmark
|
CF22-0878
|
Microbial biofilms are in the key role in degrading nutrients and organic matter in aquaculture environment, but can also harbor harmful microbes, such as producers of toxic hydrogen sulfide gas. For understanding the dynamics between beneficial and harmful microbial processes, a precise and sensitive method to map microbial metabolic substrates and products in biofilms is needed. Exactly this will be enabled by the infrastructure grant from the Carlsberg Foundation through the acquisition of an advanced motorized microprofiler setup.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_09fd862da29d29cc910f08f57a495fdd
|
Imaging Cardiovascular Function in Live Animals
|
Carlsberg Foundation
|
University of Copenhagen
|
CF19-0067
|
Not available
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_5517aa696295ae3fdbedd5b688c5fc7b
|
Reconstitution of chromosome segregation using optical tweezers
|
Carlsberg Foundation
|
University of Copenhagen
|
CF18-0305
|
Not available
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_16c884ee139953f7fb4341caa3410149
|
SPECTRO ARCOS Multiview 160 Inductively Coupled Plasma spectrometer
|
Carlsberg Foundation
|
Aarhus University
|
CF23-1261
|
Materials science is essential to the green transition and the rise of quantum information. The performance of advanced energy, quantum or biomaterials is intricately related to details of their chemical compositions. Recent advances in ICP tecnology now allows elemental identification down to part-per-billion making it possible to understand very subtle quantum effects and material behavior.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_4b78f62cdd15bcf2519d110c722f9f36
|
Instrumentation for X-ray fluorescence experiments.
|
Carlsberg Foundation
|
University of Copenhagen
|
CF18-0107
|
Not available
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_a9d6337eccae7879898e34d55f8d5ece
|
RootScan
|
Carlsberg Foundation
|
University of Copenhagen
|
CF20-0660
|
Plant roots play pivotal roles for terrestrial ecosystem functionality, as roots determine plant water and nutrient uptake, and drive ecosystem carbon storage. Yet, roots remain understudied ecosystem components. We quantify above- and belowground plant functional responses to experimental climate change in the Arctic. Currently we spend substantial excess time on manual image data validation and cleaning due to scanning artefacts arising from using non-specialized instruments. Using a new optical scanner built exclusively for root analyses will greatly reduce root data acquisition time and scanning artefacts. Ultimately, this will allow us to focus our research efforts on producing high quality, novel root data in relation to climate change effects on ecosystems and biodiversity.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_54cd9d882787b65a799a406cfa25afc7
|
Instrumentation for frequency encoded imaging of upconversion nanoparticles in the NIR region
|
Carlsberg Foundation
|
University of Copenhagen
|
CF21-0078
|
Emission-based imaging has had a large impact on science and society, especially in bio-related and medical areas. Developing new imaging techniques in the tissue transparent near infrared (NIR) region of the electromagnetic spectrum will further these developments. The grant will allow us to buy 2 pump lasers for two tunable NIR lasers which will allow us to build a dedicated wide-field microscopy setup for exploring NIR imaging with Lanthanide-based nanoparticles.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_e4ae5d76d25b08848228d66e2480df25
|
Targeting Solute Carriers using Recombinant Antibodies.
|
Carlsberg Foundation
|
Aalborg University
|
CF21-0437
|
Membrane proteins play an essential role in translating extracellular cues into intracellular responses, a feature making them attractive drug targets. Thus, it is not surprising that while membrane proteins make up around 30% of human genes, they account for over 60% of all drug targets. The solute carrier (SLC) superfamily constitutes the largest group of membrane proteins, transporting a vast array of important molecules across membranes. This superfamily of membrane proteins include more than 450 proteins. Despite being attractive and druggable targets, the SLCs, for a major part, remains understudied. Availability of reliable and validated tools to study the distribution, function and behavior remain a major bottleneck. In the current project we select recombinant antibodies for SLCs. What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_6d437afb40b0ec8365c1373a70b2957c
|
New Insights into the Recent Past of the Greenland Ice Sheet from Old Radar Data.
|
Carlsberg Foundation
|
Geological Survey of Denmark and Greenland
|
CF19-0698
|
In summer 2019, scientists from the Technical University of Denmark, Stanford University and the Geological Survey of Denmark and Greenland scanned the DTU archives of ice-penetrating radar data. Our work will make it possible to analyse the data using modern-day techniques. In this project, we will continue our work digitizing and analysing this important dataset. The data contains information on the recent past of the Greenland ice sheet, and they can tell us more about the state of the ice sheet in the 1970s. This will help us understand the present state of the Greenland ice sheet, and how it will respond to a warmer climate in the future.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_765e5ac132e0c7df4783b470cc3b3e1c
|
Single molecule RNA:Protein interaction dynamics
|
Carlsberg Foundation
|
Aarhus University
|
CF21-0086
|
Cellular life is driven by biological molecules dynamically interacting with, and dissociating from, one another. A central task of cells is to decode the information stored in the genome to produce RNA, which in-turn serves as a template for protein synthesis. In addition, many RNAs serve autonomous functions or get rapidly degraded. A complex machinery is therefore employed to sort RNAs for their correct destinies, the kinetic operation of which cannot be captured with present techniques. We will here measure the dynamics of RNA: Protein interactions at single molecule resolution by total internal reflection fluorescence microscopy. Since numerous diseases are linked to aberrant RNA-Protein interactions, our results will be of relevance for basic as well as applied biomedical research.What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_f492a77dd35f5656482c37836ea3b291
|
Danish Center for Advanced Cell Analysis – Strengthening natural and biomedical sciences to promote translational research
|
Novo Nordisk Foundation
|
University of Southern Denmark, Odense
|
NNF22OC0075258
|
The study of cells and their functions in our body is crucial for understanding mechanisms of disease, and thereby allow the development of new diagnostic methods and drugs. At University of Southern Denmark (SDU), we aim to establish the “Danish Center for Advanced Cell Analysis”, a reference center for the analysis and isolation of any type of cells from body fluids or organs, derived from human or animal models of disease. Led by a team of top scientists from the Faculty of Health Sciences and the Faculty of Natural Sciences at SDU, the center will be placed centrally within the new building for Health Sciences, which connects the new hospital to main university campus. Equipped with the most advanced instruments for analyzing cells, called flow-cytometers, this center will promote substantial innovation and raise the quality of biomedical research at SDU, thereby creating the ideal environment for new ground-breaking discoveries that will benefit our society in the future.
|
Research Infrastructure / Infrastructure / Award
| 7research_infrastructure
|
gen_ca91b5e003374cf551f54f05cf0d05e0
|
Equipment to understand the effect of calcium-sensing receptor activation
|
Carlsberg Foundation
|
University of Southern Denmark
|
CF21-0470
|
Calcium is maintained within a tight physiological range by calcium sensing receptor. The exact functions of the receptor in kidney have not been determined in sufficient detail and we have new indications about how they are activated. We received a generous grant from the Carlsberg Foundation for an ion chromatography system that allows measurements of all relevant anions and cations, whereas we have previously determined all divalent cations and anions by colorimetric assays. The system works with an autosampler, so that much less hands-on activity is required. In this project we aim to acquire an additional ion chromatography column, as this will expand system capabilities even more, to allow simultaneous measurements of both types of ions from the same sample preparation. What? Why? How?
|
Research Infrastructure / Research Infrastructure / Award
| 7research_infrastructure
|
gen_fe6d4552a67bbc4a7ef615be91987f35
|
Aerosols, Clouds, and Trace gases Research InfraStructure
|
European Commission
|
University of Leeds; Paul Scherrer Institute
|
CORDIS-654109
|
ACTRIS-2 addresses the scope of integrating state-of-the-art European ground-based stations for long term observations of aerosols, clouds and short lived gases capitalizing work of FP7-ACTRIS. ACTRIS-2 aims to achieve the construction of a user-oriented RI, unique in the EU-RI landscape. ACTRIS-2 provides 4-D integrated high-quality data from near-surface to high altitude (vertical profiles and total-column), relevant to climate and air-quality research. ACTRIS-2 develops and implements, in a large network of stations in Europe and beyond, observational protocols that permit harmonization of collected data and their dissemination. ACTRIS-2 offers networking expertise, upgraded calibration services, training of users, trans-national access to observatories and calibration facilities, virtual access to high-quality data products. Through joint research activities, ACTRIS-2 develops new integration tools that will produce scientific or technical progresses reusable in infrastructures, thus shaping future observation strategies. Innovation in instrumentation is one of the fundamental building blocks of ACTRIS-2. Associated partnership with SMEs stimulates development of joint-ventures addressing new technologies for use in atmospheric observations. Target user-groups in ACTRIS-2 comprise a wide range of communities worldwide. End-users are institutions involved in climate and air quality research, space agencies, industries, air quality agencies. ACTRIS-2 will improve systematic and timely collection, processing and distribution of data and results for use in modelling, in particular towards implementation of atmospheric and climate services. ACTRIS-2 invests substantial efforts to ensure long-term sustainability beyond the term of the project by positioning the project in both the GEO and the on-going ESFRI contexts, and by developing synergies with national initiatives.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_f0dcf7febf3fe57fd8613cf28cd5a17b
|
EMSO implementation and operation: DEVelopment of instrument module
|
European Commission
|
HELLENIC CENTRE FOR MARINE RESEARCH; Universidade do Porto
|
CORDIS-676555
|
The EMSODEV general objective is to catalyse the full operations of the EMSO distributed Research Infrastructure, through the development and deployment of the EMSO Generic Instrument Module (EGIM). EGIM will provide accurate, consistent, comparable, long-term measurements of ocean parameters, which are key to addressing urgent societal and scientific challenges (e.g. climate change and hazards). This will lead to an increased interoperability of EMSO nodes and to the common collection of ocean essential variable time series. The specific objectives are: (1) to design and implement a state-of-the-art, standardized multidisciplinary EGIM, a common, harmonized, observation system; (2) to fully test, calibrate, validate and assess the effectiveness of this innovative module in order to ensure its maximum quality, long-term durability, and reliability; (3) to strengthen the data management and delivery backbone of the EMSO RI; this will require a coordinated approach to data capture, archiving, management, and delivery, in turn spurring the development of a wide range of data products and services; (4) to promote the uptake of the project results and public-private partnerships establishing links with industry and SMEs for technology transfer. These objectives will be achieved through: (a) Research & Innovation activities focused on the design, development, test, replication and deployment of EGIMs at EMSO nodes and data management system implementation; (b) Communication, dissemination and exploitation activities aimed at disseminating and facilitating the uptake of the project results, and setting up activities to increase the innovation potential of EMSODEV technological output, and to explore EGIM commercialization. All these activities are in line with those listed in the part B of the section “Specific features for Research Infrastructures”. The consortium includes 11 multi-skilled partners, with two industries, ensuring the fulfilment of the objectives.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_4f88587daf4ed9902dcd4906736da819
|
EPOS Implementation Phase
|
European Commission
|
INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU FIZICA PAMANTULUI
|
CORDIS-676564
|
The nations of Europe are distributed around some of the most complex and dynamic geological systems on the planet and understanding these is essential to the security of livelihoods and economic power of Europeans. Many of the solutions to the grand challenges in the geosciences have been led by European scientists – the understanding of stratigraphy (the timing and distribution of layers of sediment on Earth) and the discovery of the concept of plate tectonics being among the most significant. Our ability to monitor the Earth is rapidly evolving through development of new sensor technology, both on- and below-ground and from outer space; we are able to deliver this information with increasing rapidity, integrate it, provide solutions to geological understanding and furnish essential information for decision makers. Earth science monitoring systems are distributed across Europe and the globe and measure the physico-chemical characteristics of the planet under different geological regimes. EPOS will bring together 24 European nations and combine national Earth science facilities, the associated data and models together with the scientific expertise into one integrated delivery system for the solid Earth. This infrastructure will allow the Earth sciences to achieve a step change in our understanding of the planet; it will enable us to prepare for geo-hazards and to responsibly manage the subsurface for infrastructure development, waste storage and the use of Earth’s resources. With a European Research Infrastructure Consortium (ERIC) to be located in Rome (Italy), EPOS will provide an opportunity for Europe to maintain world-leading European Earth sciences and will represent a model for pan-European federated infrastructure.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_4854a7b7a5164e12773392f10e36c090
|
PRACE 5th Implementation Phase Project
|
European Commission
|
PARTNERSHIP FOR ADVANCED COMPUTINGIN EUROPE AISBL; Universität Stuttgart
|
CORDIS-730913
|
PRACE, the Partnership for Advanced Computing is the permanent pan-European High Performance Computing service providing world-class systems for world-class science. Systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 11 billion core hours of compute time. HPC experts from 25 member states enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is in transition to PRACE 2, the successor of the initial five year period. The objectives of PRACE-5IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2 including an analysis of Trans National Access; strengthening the internationally recognised PRACE brand; continuing and extend advanced training which so far provided more than 18 800 persontraining days; preparing strategies and best practices towards Exascale computing; coordinating and enhancing the operation of the multi-tier HPC systems and services; and supporting users to exploit massively parallel systems and novel architectures. A high level Service Catalogue is provided. The proven project structure will be used to achieve each of the objectives in 6 dedicated work packages. The activities are designed to increase Europe's research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and new communities and special offers to SMEs; implementing a new flexible business model for PRACE 2; proposing strategies for deployment of leadership systems; collaborating with the ETP4HPC, CoEs and other European and international organisations on future architectures, training, application support and policies. This will be monitored through a set of KPIs.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_d33a2f2d2325045b7be61510398be4f4
|
Integrating Research Infrastructure for European expertise on Inclusive Growth from data to policy
|
European Commission
|
Conservatoire National des Arts et Metiers
|
CORDIS-730998
|
Referring to the increasingly challenging EU2020-ambitions of Inclusive Growth , the objectives of the InGRID-2 project are to advance the integration and innovation of distributed social sciences research infrastructures (RI) on ‘povety, living conditions and social policies’ as well as ‘working conditions, vulnerability and labour policies’. InGRID-2 will extend transnational on-site and virtual access, organize mutual learning and discussions of innovations, and improve data services and facilities of comparative research. The focus areas are a) integrated and harmonized data, (b) links between policy and practice, and (c) indicator-building tools. Lead users are social scientist involved in comparative research to provide new evidence for European policy innovations. Key science actors and their stakeholders are coupled in the consortium to provide expert services to users of comparative research infrastructures by investing in collaborative efforts to better integrate micro-data, identify new ways of collecting data, establish and improve harmonized classification tools, extend available policy databases, optimize statistical quality, and set-up microsimulation environments and indicator-building tools as important means of valorization. Helping scientists to enhance their expertise from data to policy is the advanced mission of InGRID-2. A research portal will be the gateway to this IRI. Networking activities will provide initiation (summer schools), in-depth discussions (expert workshops), and help to promote necessary innovations for sustainable inclusive growth. Extending the RI to all EU countries is an important mission on the agenda for InGRID-2. Based on surveyed users’ needs, joint research activities are conducted in the focus areas and concentrate on extending data integrations, exploring new data linkage and sources, innovating microsimulation tools, improving comparative policy data, and investigating new high-quality indicators.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_881d563cccfbf803c117511299c45c66
|
ACTRIS PPP - Aerosols, Clouds and Trace gases Preparatory Phase Project
|
European Commission
|
NATIONAL INSTITUTE OF RESEARCH AND DEVELOPMENT FOR OPTOELECTRONICS
|
CORDIS-739530
|
The Research Infrastructure (RI) ACTRIS – Aerosols, Clouds and Trace Gases - is the pan-European RI that consolidates activities amongst European partners for observations of aerosols, clouds, and trace gases and for understanding of the related atmospheric processes, to provide RI services to wide user groups. ACTRIS is composed of 8 connected elements: distributed National Facilities (observation platforms and exploratory platforms) both in Europe and globally, and 7 Central Facilities (Head Office, Data Centre and 5 Calibration Centres). ACTRIS provides access to its facilities, open-access data, research support, instrument calibration and development, and training to various user groups. By providing data and access ACTRIS enhances science, but it also generates and disseminates knowledge, boosts technological development, and creates human capital and jobs for the benefit of the society. ACTRIS will positively impact on e.g. human health, climate resilience, and protection from environmental hazards and reduction of air pollution. ACTRIS has been selected to the ESFRI roadmap in 2016 as mature enough to be implemented within the next ten years. ACTRIS Preparatory Phase Project (PPP) will have a significant role in enabling the transition from a project-based network of research facilities to a centrally coordinated integrated pan-European RI. ACTRIS PPP brings together a wide community of research performing organizations, research funding organizations and ministries needed to take the decisions and actions to move forward in the implementation of the ACTRIS. The main objectives of ACTRIS PPP are to develop the organizational, operational and strategic frameworks of the RI. The work includes legal, governance, financial, technical, strategic, and administrative aspects carried out in 9 work packages. The main outcomes of PPP are signature-ready documents for establishment of a legal entity with well-defined operations and a sound business plan.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_02c6a15be891e9072323f2861a405344
|
PREPARATORY PHASE FOR THE PAN-EUROPEAN RESEARCH INFRASTRUCTURE DANUBIUS–RI “THE INTERNATIONAL CENTRE FOR ADVANCED STUDIES ON RIVER-SEA SYSTEMS
|
European Commission
|
BUNDESANSTALT FUR WASSERBAU
|
CORDIS-739562
|
DANUBIUS-PP is a three-year project to raise DANUBIUS-RI (International Centre for Advanced Studies on River-Sea Systems) to the legal, financial and technical maturity required for successful implementation and development. DANUBIUS-RI is a pan-European distributed research infrastructure (RI) building on existing expertise to support interdisciplinary research on river-sea (RS) systems, spanning the environmental, social and economic sciences. It will provide access to a range of RS systems, facilities and expertise, a ‘one-stop shop’ for knowledge exchange, access to harmonised data, and a platform for interdisciplinary research, education and training. DANUBIUS-PP will bring together key stakeholders at different levels, and strengthen the consortium through a process of wide engagement. Individual work packages will refine, inter alia, the scientific and innovation agenda, the legal framework, governance and management, and policies for access and data management. The financial requirements of the RI will be refined to assist funding agencies as they consider future spending priorities. Key deliverables of DANUBIUS-PP include development of the legal and financial agreements for the components of the RI (including Hub, Nodes and Supersites), their governance, and internal organisation which will be confirmed via a Memorandum of Understanding. This preparatory phase project will develop the structures and processes to ensure that the RI strengthens scientific performance by providing a sustainable basis for future operation, delivering key services to the different user communities.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_b7c72bbce895db3b670cfd5bbd286e8a
|
Aerosol, Clouds and Trace Gases Research Infrastructure Implementation Project
|
European Commission
|
Université Paris 12 - Paris-Est Créteil Val-de-Marne; INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
|
CORDIS-871115
|
The Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS) is a pan-European research infrastructure producing high-quality data and information on short-lived atmospheric constituents and on the processes leading to the variability of these constituents in natural and controlled atmospheres. Different atmospheric processes are increasingly in the focus of many societal and environmental challenges, such as air quality, health, sustainability and climate change. ACTRIS brings essential information for understanding atmospheric processes and bio-geochemical interactions between the atmosphere and ecosystems. ACTRIS is composed of Observational and Exploratory Platforms, Topical Centres, Data Centre, and Head Office that is coordinating the ACTRIS activities. ACTRIS serves a vast community of users such as scientists, policy makers, private sector, funding organisations and educators. ACTRIS activity started almost 20 years ago, and currently more than 100 European partners from 22 countries are engaged in building the research infrastructure. ACTRIS was selected to the ESFRI roadmap in 2016 and was granted with EC preparatory phase project funding (ACTRIS PPP) for 2017-2019. Interim ACTRIS Council (IAC), representing the governmental representatives of 16 member countries and one observer country, have submitted the ACTRIS ERIC step 1 documents to EC in Feb 2019. IAC is aiming to establish ACTRIS ERIC in 2021. ACTRIS is entering the implementation phase in 2020. The ACTRIS implementation project, ACTRIS IMP, will take ACTRIS into a new level of maturity and will set the needed structures for the implementation actions, both at the national and European level. ACTRIS IMP builds on three main pillars: securing the long-term sustainability, implementing of ACTRIS functionalities, and positioning ACTRIS in the national, European and international science and innovation landscape. ACTRIS IMP will enable ACTRIS to respond to the users’ needs and requirements.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_9c6619500c315a1b9d53b17a1e652880
|
Research on AI- and Simulation-Based Engineering at Exascale
|
European Commission
|
Flanders Make
|
CORDIS-951733
|
Compute- and data-driven research encompasses a broad spectrum of disciplines and is the key to Europe’s global success in various scientific and economic fields. The massive amount of data produced by such technologies demands novel methods to post-process, analyze, and to reveal valuable mechanisms. The development of artificial intelligence (AI) methods is rapidly proceeding and they are progressively applied to many stages of workflows to solve complex problems. Analyzing and processing big data require high computational power and scalable AI solutions. Therefore, it becomes mandatory to develop entirely new workflows from current applications that efficiently run on future high-performance computing architectures at Exascale. The Center of Excellence for Research on AI- and Simulation-based Engineering at Exascale (RAISE) will be the excellent enabler for the advancement of such technologies in Europe on industrial and academic levels, and a driver for novel intertwined AI and HPC methods. These technologies will be advanced along representative use-cases, covering a wide spectrum of academic and industrial applications, e.g., coming from wind energy harvesting, wetting hydrodynamics, manufacturing, physics, turbomachinery, and aerospace. It aims at closing the gap in full loops using forward simulation models and AI-based inverse inference models, in conjunction with statistical methods to learn from current and historical data. In this context, novel hardware technologies, i.e., Modular Supercomputing Architectures, Quantum Annealing, and prototypes from the DEEP project series will be used for exploring unseen performance in data processing. Best practices, support, and education for industry, SMEs, academia, and HPC centers on Tier-2 level and below will be developed and provided in RAISE's European network attracting new user communities. This goes along with the development of a business providing new services to various user communities.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_076acfba9db100cf6c4823ac631688f2
|
STRIDES
|
NIH
|
FOUR POINTS TECHNOLOGY, LLC
|
3OT2OD027852-02S6
|
The Science and Technology Research Infrastructure for Discovery, Experimentation, and Sustainability (STRIDES) Initiative establishes partnerships with commercial cloud service providers (CSPs) to reduce economic and technological barriers to accessing and computing on large biomedical data sets to accelerate biomedical advances. A central tenet of the STRIDES Initiative is that data made available through these partnerships will incorporate standards endorsed by the biomedical research community to make data Findable, Accessible, Interoperable, and Reusable (FAIR). Stylized cloud image with interconnected nodes representing cloud computingThe STRIDES Initiative will help to address the NIH Strategic Plan for Data Science goals to modernize the biomedical data ecosystem and support storage and sharing of individual datasets by testing and assessing models of cloud infrastructure for NIH-funded data sets and repositories. Through the partnerships established by the STRIDES Initiative, CSPs will work directly with the NIH and its funded investigators to develop and test new ways to make large data sets and associated computational tools available and accessible by wider audiences. CSPs and investigators of the NIH Data Commons Pilot Phase will set up cloud storage and services for the three test case data sets used to develop principles, policies, and processes for the Data Commons. Services are expected to become available to the NIH-supported community after a series of pilot programs to refine policies and procedures for the initiative.
|
Other
| 7research_infrastructure
|
gen_a8fe1a3869f6ec0a8286501030b5daf9
|
DEVELOPMENT OF INTERMODAL EXCHANGE CENTER ROUEN RIGHT BANK STATION AND SURROUNDINGS
|
Kohesio
|
METROPOLE ROUEN NORMANDIE
|
https://linkedopendata.eu/entity/Q3681251
|
Rouen station is a major facility in the Metropolis and the Upper Normandy region. With 6 million travelers per year, it is the 15th station in France in terms of traffic. The station and its surroundings are used daily by travelers, tourists, motorists in transit, but also by residents of the city. The use of this space is thus materialized through the use of different modes of travel. Also, the superposition of traffic and modes, the coexistence of exchanges and flows generate circulation difficulties, problems of service and accessibility of the station (TC penalized by traffic, illegal parking, etc.), conflict zones for soft modes (including problematic crossing of boulevards), and public spaces that are saturated, illegible and unwelcoming for the traveler and the user. Furthermore, the spatial and functional articulation between the North-South Arc and the surroundings of the Rouen Right Bank station is necessary so that the future Bus High Level of Service (B.H.N.S.) is efficiently connected to the tramway and the station. This optimized articulation will allow it to play the structuring role that must be assigned to exchange hubs in travel networks in order to make the train an everyday mode of urban transport.
|
Connected Europe / Network infrastructure in transport and energy / Intelligent transport systems (including the introduction of demand management, tolling systems, IT monitoring, control and information systems)
| 7research_infrastructure
|
gen_dea3855e9b2fdd8eddf9c32e0ad3f1da
|
FEDER - IFREMER - FMRID
|
Kohesio
|
EPIC IFREMER
|
https://linkedopendata.eu/entity/Q3680383
|
Microplastics (MP) are emerging but ubiquitous contaminants in all compartments of the marine environment, from coastal to offshore, in estuaries, on the surface or at the bottom. They are detected in all regions of the world, including Antarctica. Regionally, few studies have been carried out to assess contamination of the aquatic environment. However, the Seine estuary is likely to be heavily contaminated by micro-plastics following urban pressures and the numerous port and industrial activities present within it or upstream. The preliminary results of the Plastic-Seine project (IFREMER LER/N and LEESU) show the widespread contamination of our environments by micro-plastics, whether in the water column, sediment but also biota. If these first results provide a first overview of the contamination, to date, their representativeness in time and space, their spatio-temporal distribution on a fine scale is unknown due in particular to a limited number of campaigns carried out. Indeed, high costs (financial and time), rapid clogging of the sampling nets linked to the significant turbidity of the Seine and extremely time-consuming analysis time are all constraints. These questions of representativeness are key in understanding the dynamics of micro-plastics at the scale of a watershed and implicitly in the development of management strategies or the definition of reduction measures. The sampling methods and analytical rates of the methods currently deployed do not make it possible to answer questions about the variability of the distribution of PM depending on the different forcings (e.g. flow, waves, tide). Finally, some studies suggest an underestimate of the contamination of the “water” matrix to the extent that synthetic fibers and nano-beads from cosmetic products are not retained. At the same time, techniques such as Raman spectroscopy or ITRF are commonly used to identify the nature of polymers. However, for reasons of time, identification is often carried out on only part of the samples. Semi-qualitative or qualitative techniques are also developed but are poorly suited to fiber detection. Many authors have thus shown that around 20 to 40% of particles initially determined as micro-plastic particles were in fact non-plastic materials. Faced with these technical obstacles, it is therefore necessary to provide innovative methodological elements in terms of sampling and detection of micro-plastics.
|
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 7research_infrastructure
|
gen_b4a351e17d9802b1e1822a496d43b4bb
|
FEDER - UNICAEN - RNAMB - INVEST
|
Kohesio
|
UNIVERSITE DE CAEN NORMANDIE
|
https://linkedopendata.eu/entity/Q3673781
|
The term “Microbiota designates complex microbial communities and is today at the center of multiple concerns. In the human body, where the microbial population is estimated at 1.5 kg, or 1014 microorganisms and 10 times more than human eukaryotic cells, there are 2 main microbiota, the intestinal microbiota (1 kg) and the skin microbiota (200 g). The intestinal microbiota has been extensively studied but it is only much more recently that the structure and functions of the skin microbiota have been addressed, in particular under pressure from the cosmetic industry. We also find an airborne microbiota linked to aerosols, essential in the diffusion of pathogens, and in foods where it participates in both their maturation and their spoilage. These microbiota are composed of bacteria but also molds (fungal microbiota), yeasts and viruses. Certain viruses (bacteriophages, targeting bacteria) are suspected of playing an essential role on the dynamics of the bacterial microbiota, and therefore on the final technological and health qualities of foods. In different environments and as soon as they are in contact with stable surfaces, microorganisms organize themselves in the form of biofilms which can be considered as “transient tissues within which they produce an extracellular matrix and communicate by chemical or even electrical signals. This development in the form of biofilms is associated with significant physiological modifications which generally give microorganisms increased resistance to biocides. The enbiofilm growth of bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii or Legionella pneumophila is thus associated with increased resistance to antibiotics and the development of highly morbid chronic infections, as in the case of cystic fibrosis. At the same time, in the environment the development of microbial biofilms leads to modifications of the surface of materials and to their alteration (corrosion), or even as in the case of marine biofilms (biofouling), to the attachment of undesirable organisms (invertebrates, algae, etc.) or to the contamination of foods. The modifications of microorganisms linked to the transition from the planktonic (free) lifestyle to the biofilm lifestyle have been the subject of studies on germs isolated or on model biofilms that are generally simple or reconstituted from a limited number of species, whereas in reality biofilms present a very great diversity. On the other hand, there are transient or permanent life forms of microorganisms on surfaces such as the skin which, with a few exceptions, do not really seem to be biofilm-structured but nevertheless imply a high level of adaptation to their micro and macroenvironment. It has thus been shown that signals from the host (hormones, neurohormones) and atmospheric pollutants (NO2) can be detected by microorganisms (bacteria) and modulate their virulence and their capacity to form biofilms. It is therefore necessary in a large number of cases to study the composition and functionality of real complex microbiota, whether in free form (air), in interaction with their host (skin) or parasites (bacteriophages) and their environment (atmospheric pollutants of the NO2 type) and in the form of biofilms (food) in order to better understand their positive and/or deleterious effects and if necessary define new active ingredients making it possible to control health safety, well-being and food sustainability. This last objective involves the characterization of the regulatory mechanisms involved in the formation of these microbiota. This project is therefore based on the development of specific high-throughput screening techniques.
|
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 7research_infrastructure
|
gen_9e07f849bfc03ee0623e17e01248e1b8
|
FEDER - CNRS - PLDSURF - TREMPLIN
|
Kohesio
|
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
|
https://linkedopendata.eu/entity/Q3680279
|
The CRISMAT laboratory, in partnership with CIMAP, aims to acquire large area laser ablation equipment, in order to support its thin film activities, and in particular activities on the new transparent conductor SrVO3. These materials, transparent conductors, are necessary when it is necessary to combine transparency with visible light and electrical contact, which is the case in a wide range of applications such as flat or touch screens, photoluminescent diodes or even photovoltaic cells. Indium tin oxide (ITO), the industrial standard material, suffers from the scarcity of one of the constituent elements, Indium, which has led to strong research activity to identify alternative transparent conductors without Indium. With its properties comparable to ITO, SrVO3 offers itself as an alternative material, whose character as a transparent conductor was only demonstrated in 2016. Being active in research using SrVO3 for several years, CRISMAT has focused its efforts on the development and especially on the integration of this perovskite type oxide on low-cost substrates, in partnership with CIMAP. During the Labex EMC3 “COTRA (2017/2018) joint project, we were able to highlight the technological interest of this material and demonstrate its integration on glass, which is currently the subject of a patent application. SrVO3 is also one of the research subjects of the ANR project “Polynash (2018 2022), which aims to integrate complex oxides on low-cost substrates through the use of nanosheets. We are then able to use a wide range of substrates to develop thin crystalline layers of this new transparent conductor. However, there is still an important technological obstacle to overcome to consider technology transfer: large-area deposition. Our deposition technique, pulsed laser ablation (PLD Pulsed laser Deposition) is one of the techniques best suited to the deposition of thin layers of this type of oxide, but requires suitable equipment for large surfaces to allow laser scanning over larger surfaces. Such equipment will allow us to offer samples approaching the sizes used in the industrial world, promoting exchanges with these players, for easier technological transfer not only of SrVO3, but also of other functional materials.
|
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 7research_infrastructure
|
gen_36d63dae04273dbf86f91d0e3790f23c
|
FEDER - ENSICAEN - SUNRISE - EMERGENT
|
Kohesio
|
ECOLE NATIONALE SUPERIEURE INGENIEURS
|
https://linkedopendata.eu/entity/Q3680381
|
A typical solar H2 and O2 production system is generally composed of 4 elements: (i) a photoanode, (ii) a (photo)cathode (iii) an electrolyte, and (iv) a membrane or separator The photodissociation of water by electro-photo-catalysis takes place in stages: (i) absorption of photons by an n-type semiconductor (SC) at the anode generates the creation of electron-hole pairs (ii) oxidation of water into the elements O2 and H+ of water by reaction with the holes at the anode (iii) transport of electrons by an external circuit to the PEC cell and of H+ protons in the electrolyte (iv) reduction of H+ protons by electrons at the cathode and production of hydrogen H2. The two photoelectrodes are connected via the external circuit to the PEC equipped with a generator to apply the appropriate potential. The separation of the photocarriers in the anode and the cathode generated by the radiation is ensured by the existence of an internal electric field in the space charge zone produced by a PN or NP junction type structure or at the interface with the electrolyte, this is the photocurrent. The photocarriers generated in the photoelectrode outside the space charge zone diffuse and give rise to the diode current (diffusion).
|
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 7research_infrastructure
|
gen_1214269c5d15373216bf0b2099620409
|
FED INV -18E01076- ITI ST LO - DIGITAL REFERENCE LIBRARY
|
Kohesio
|
COMMUNE DE SAINT LO
|
https://linkedopendata.eu/entity/Q3673817
|
The city of Saint-Lô has chosen to make the media library the essential cultural resource center of the region and to commit the structure to an ambitious work program and to set up a digital library model: a library of tomorrow entirely designed and structured with regard to the evolution of our lifestyles and our cultural practices. This global digital development plan concerns both the modernization of equipment, the development of online services and access to heritage resources. The “Digital Reference Library” program, initiated by the Ministry of Culture and Communication, aims to provide communities with high-level digital libraries. Obtaining this national label will make it possible to identify the establishment as a regional resource location. The Saint-Lô library, by fundamentally rethinking the organization of its physical spaces, aims to strengthen its positioning at the heart of the cultural and social activity of the territory. The development of hybrid services, which combine physical media and access to dematerialized resources is the principle of development of this new space, which must allow access, from all points of the library to the Internet, and to digital resources, from the users' own materials and stations located in the library.
|
Smarter Europe / Information and communication technology / e-Inclusion, e-Accessibility, e-Learning and e-Education services and applications, digital literacy
| 7research_infrastructure
|
gen_818965832eda21947d4bddf5dfa52a18
|
FEDER - URN - AXONE-GLIOMA
|
Kohesio
|
UNIVERSITE DE ROUEN-NORMANDIE
|
https://linkedopendata.eu/entity/Q3681905
|
Background of the proposalGlioblastoma multiforme is a glioma, a tumor of glial origin. It is the most common primary tumor of the central nervous system in adults, associated with very high morbidity and mortality, particularly due to its very invasive nature1. Particularly aggressive, these tumors give rise to almost systematic recurrences and the median survival after resection, radiotherapy and/or chemotherapy is less than 15 months. This poor prognosis is partly linked to the invasive nature of glial tumor cells, which actively infiltrate the brain parenchyma, being able to migrate away from the main tumor mass. These disseminated cells escape focal therapies and can give rise to new tumor foci distant from the initial tumor1. Understanding the mechanisms favoring the dissemination of cancer cells in the brain is therefore necessary to consider new therapeutic avenues and the development of curative treatments. In the brain, glioblastoma cells infiltrate the breast parenchyma by borrowing elements of pre-existing tissue. They migrate mainly along blood vessels and along the fibrous tracts of the white matter, and more rarely take the ventricular route2. The migration of tumor cells along blood vessels is well characterized and leads to damage within the gliovascular unit, a breakdown of the blood-brain barrier, accompanied by a probable deficit in nutrient supply3. The migration of tumor cells along myelinated nerve fibers has been poorly characterized. It has long been relegated to the rank of a simple passive process, with the white matter providing a permissive environment of low resistance for the migration of single tumor cells or in small groups4. However, recent data suggest that these invasion phenomena could be more complex5 and modulated by the activity of the local tumor environment; See attached file
|
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 7research_infrastructure
|
gen_fca073d0d91fd08ee0be61f8567a11f1
|
REQUALIFICATION OF LOUIS RICHARD WORKSHOPS
|
Kohesio
|
COMMUNE DE LE HAVRE
|
https://linkedopendata.eu/entity/Q3680512
|
The Natural History Museum of Le Havre is embarking on an ambitious museum center project comprising several aspects: - an exceptional collections project transformed into an integration project in order to prepare for the move to new reserves, - a project for new museum reserves through the rehabilitation of the Ateliers Louis Richard building - a modernization of the Museum, old market square, current place of exhibition and entertainment and public reception; - a project to rehabilitate the old Jean School Macé, old market square, in order to considerably extend and increase the spaces dedicated to the public (library, activities, permanent exhibition, etc.) The operation described here concerns more particularly the project of new museum reserves, located in the Metropolitan Curr. In addition to the proper functioning of the museum, the objective is to diversify the activity of this territory and to provide it with new vocations, as well as to improve the living environment. The new reserves will make it possible to accommodate researchers and individuals in good conditions. Storage conditions will also be greatly improved, making it possible to better preserve and enhance Le Havre's heritage and enrich the collections. The cultural influence of the Le Havre region will be strengthened. The former Louis Richard Workshops also house the French Lines reserves, which have been the subject of work in recent years (not financed as part of this project).
|
Greener, carbon-free Europe / Environment protection and resource efficiency / Rehabilitation of industrial sites and contaminated land
| 7research_infrastructure
|
gen_935f7e52fd16c589c3b47e9ef6e7b067
|
FEDER - UNICAEN - CPER MANCHE 2021 - INVEST
|
Kohesio
|
UNIVERSITE DE CAEN NORMANDIE
|
https://linkedopendata.eu/entity/Q3673799
|
The “Manche 2021” project is organized around 3 actions: “Integrated and sustainable coastal management,” “Marine resources and aquaculture and “Marine renewable energies.” The context of the operation “Channel 2021-Platforms for the exploitation of marine resources, 2017-2019, is part of the action “Marine renewable energies with the objectives of continuing the establishment of an electromechanical platform for tidal turbines as a modeling and simulation tool (phase 2: energy transformation and storage). This operation is also part of the “Marine resources and aquaculture” action with the objectives of setting up an animal behavior platform and acquiring a nanoLC-ESI-MS/MS for the PROTEOGEN platform of SF ICORE. The purpose of this operation is to acquire the following 3 pieces of equipment: 1- An Electromechanical Platform for the study of the fluid-structure-energy behavior of tidal turbines. It will make it possible to simulate the complete energy generation chain from mechanical capture to the injection of electrical energy into the network. It will also make it possible to address the reliability and lifespan of electrical machines to establish diagnostic and predictive maintenance algorithms for these devices. This platform is part of the strategy of the university in general and of LUSAC in particular to develop tools for decision support and prediction of the production of electrical energy produced by one or more tidal turbine farms. It will make it possible to validate the modeling and algorithms developed in the field of EMR. 2- A marine animal ethology platform which will make it possible to provide a range of behavioral tests for different marine animal species (cephalopods, fish) as part of integrative studies. 3- A nanoLC-ESI-MS/MS mass spectrometer allowing the high-throughput analysis and identification of peptides and proteins involved in the physiology of animal, plant, or bacterial organisms. This equipment will strengthen the capacities of the PROTEOGEN platform to respond to analysis requests from research units within the framework of regional, national or international partnerships.
|
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 7research_infrastructure
|
gen_9c39978ad33deb98177168e29f12fbca
|
BIOMASS IMPLEMENTATION/UPDATING OF SIVI SRCAE INDICATORS 2015-2017 DADDTE
|
Kohesio
|
ASSOCIATION REGIONALE BIOMASSE NORMANDIE
|
https://linkedopendata.eu/entity/Q3673359
|
As part of the national program to improve energy efficiency, a multi-year agreement, the purpose of which is to run an Info-Energy Space, was concluded on February 13, 2002 between ADEME and Biomasse Normandie. The Lower Normandy Region has provided financial support for this activity since 2004. At the same time, as part of the wood energy development program for collective boiler rooms, the association maintains a database listing all collective and industrial wood boiler rooms in the region. From 2004, this database was extended to individual heating operations using chipped wood then, gradually, to solar installations (thermal and photovoltaic), wind power and micro-hydraulics. At the end of the energy and greenhouse gas balance, finalized in November 2006, the Region, in partnership with ADEME, defined a Défi'NeRgie program whose objective is to reduce greenhouse gas emissions by million tonnes by 2013 (including 500,000 tonnes of CO2 for the energy sector) corresponds to half of what the "factor 4" scenario would allow. In order to evaluate the effectiveness of the various incentive measures put in place as part of Défi'NeRgie (and thus meet one of the program's objectives), the Region, ADEME Basse-Normandie and Biomasse Normandie have designed and created a database listing "renewable energy" and "energy management" (insulation programs) installations in Lower Normandy, as well as any equipment that has benefited from financial aid. The updating and evolution of this tool has made it, since 2012, the heart of the data necessary for the Lower Normandy energy and climate observatory (OBNEC). The regional objectives are now precisely detailed and quantified within the Regional Plan "Climate, Air, Energy" definitively adopted in December 2013. In order to evaluate the effectiveness of the incentive measures put in place and to position the regional results with regard to the objectives quantitatively defined previously, it is necessary to establish and update SRCAE monitoring indicators. At the same time, the programming of European funds for the period 2014-2020 has clearly identified the need to have a tool for monitoring energy consumption and production at the territorial level.
|
Greener, carbon-free Europe / Low-carbon economy / Renewable energy: biomass
| 7research_infrastructure
|
gen_79c582b552ccdb613853b5da220d3604
|
FEDER - ENSICAEN - CPER Materials Chemistry - AGIR Advanced spectroscopy - Invest
|
Kohesio
|
ECOLE NATIONALE SUPERIEURE INGENIEURS
|
https://linkedopendata.eu/entity/Q3673791
|
The Catalysis and Spectrochemistry Laboratory (LCS) is an internationally recognized laboratory for the characterization of catalysts and materials by vibrational spectroscopies, particularly in operating conditions (“operando”). We thus participated in two consecutive European projects (2009-2018) requiring our expertise in these areas. Initially specialized in the analysis of catalysts, the themes of the laboratory have evolved as well as the types of materials studied which now cover in addition to catalysts, new and hybrid materials, adsorbents or membranes, materials for energy applications... These different studies have shown the need to approach the characterization of materials and catalysts through a global approach which goes from the heart of the material to its surface. This project therefore aims to develop and upgrade its spectroscopic equipment through the acquisition of new high-performance equipment, adapted to new study conditions and new interfaces (solid/gas, solid/liquid): a Raman spectrometer intended to replace the current spectrometer and broaden its field of applications. Initially specialized in the analysis of catalysts, the laboratory's themes gradually expanded, leading to a diversification of the types of materials studied (new and hybrid materials, adsorbents, membranes, materials for energy applications, etc.) and operating conditions (low and high pressure, corrosive products, presence of water, etc.). This project therefore also aims to develop innovative equipment (AGIR), unique on a global scale, efficient and adapted to new conditions for studying catalysts and materials via the coupling of two techniques. IR spectroscopy is a technique which makes it possible to determine the nature and evolution of the species present on a sample. Thermogravimetric analysis (TGA) leads to monitoring of the variation in mass of a sample. The objective of the project is to create a new scientific tool that combines these two complementary techniques: the qualitative aspect of IR coupled with the quantitative aspect of ATG. The originality of the system is to couple a magnetic suspension microbalance specially adapted for ultra-high vacuum and high pressure to an IR materials analysis chamber. The development of control and automation functions for adding pollutants is an important part of the project. This tool should lead to better knowledge of the mechanisms of storage of pollutants and poisoning of materials in the field of automobile and air pollution control. This new system will thus contribute to strengthening the positioning of the LCS in the international and national context, but also at the local level because it will allow collaborations with other Normandy laboratories to be continued and amplified.
|
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 7research_infrastructure
|
gen_876412edb308820b5552f84ba52e97dd
|
20P00039 - IRTS - Cap'ebadge - Copy of file "17E02244"
|
Kohesio
|
IRTS NORMANDIE-CAEN ARRFIS
|
https://linkedopendata.eu/entity/Q3680470
|
The development of this project is based on an observation: the qualification rate in the home help sector is low. According to data from the SAPAD survey (home help services), only 18% of those working in a home help service have a diploma. Alongside this observation, it is difficult for employers to recruit people with profiles adapted to the difficulty of this profession and its lack of knowledge. Taking care of a dependent person, in the broad and not only medical sense of the term requires essential skills in this sector, which are sometimes acquired other than through a training course: daily organization, kindness, listening and discretion, respect for the person and their place of life, availability and their limits and respect for framework.How to evaluate these basic skills, how to help an employer recruit staff without qualifications but with the qualities necessary to start in this sector.The home help sector is one of the top 5 professions in terms of "labor needs" (Pôle emploi survey 2017). Through this operation, we wish to offer employers and people looking for work a course to promote "informal" skills. This course will be enhanced by obtaining a certificate represented by a digital badge which we will call: e-badge The course developed for this operation will be carried out in close collaboration with various employers in the home help sector in order to best meet their expectations and their needs. This course will be made up of several simulated situations encountered in the field and co-constructed with professionals in the sector. Candidates will be offered a course to complete on an LMS (Learning Management System) type training platform. This course will be made up of several “virtual” scenarios designed using behavioral simulation software. Different modules will represent these virtual situations, these will be written in the form of a “storytelling each presenting a specific situation. Each module will be constructed as a tree of scenarios which will be written during the evaluation based on the responses provided by the candidate to each scene. At the end of the module, a radar-type graph will present the level of skills achieved by the candidate on all stages. When completing the course, particular attention will be taken into account to support the candidate in completing this course in the best conditions depending on their environment (accompanied during a job interview or alone on a training platform). We will take into account that the target audience may have great difficulty using a tablet or a computer. Several modules will be offered to assess skills in several contexts. At the end of the course, all skills validation rates will be taken into account in order to validate obtaining the e-badge. This e-badge will be on the one hand a digital icon whose metadata (the identity of the receiver, the issuer, the award criteria and the supporting documents) will be deposited on a platform hosting this type of device and on the other hand a real object given to the candidate including a "QR code allowing access to the metadata. This e-badge will allow for: candidates to promote their informal skills, to complete their CV employers to consolidate a job interview prescribers to best guide job seekers Ultimately this e-badge will make it possible to: avoid poor referrals towards home help optimize the time dedicated to recruitment for employers to be a pilot in the promotion of informal skills
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Smarter Europe / Information and communication technology / ICT: Other types of ICT infrastructure/large-scale computer resources/equipment (including e-infrastructure, data centres and sensors; also where embedded in other infrastructure such as research facilities, environmental and social infrastructure)
| 7research_infrastructure
|
gen_c074d4b617f5d6da5c58de7ec6ffb707
|
FED INV-16P03372-COUTANCES- CITIZEN PORTAL
|
Kohesio
|
COMMUNE DE COUTANCES
|
https://linkedopendata.eu/entity/Q3673575
|
PresentationThe town of Coutances has just over 8,000 inhabitants at the last census. It is a city known for its internationally renowned Jazz festival, which attracts 70,000 festival-goers in 10 days. Coutances is a “city of art and history” and its cathedral and its most representative building. Web communicationUntil now Coutances had a purely informative site created 4 years ago. 5000 to 6500 visitors pass through the site each month. However, this site is heavy to load due to its design (multiple responsive zones, tables, justified texts), has a fixed menu that does not allow it to be adapted to changing needs (reactive zones need to retouch the template to retouch the menu). Outside of the site, no service to the public is offered other than referrals to “service-public.fr” Note that Coutances has its Facebook page, created in February 2015 and with almost 900 subscribers. If the website lacks dynamism and a rigid ergonomics does not allow the information to be brought to life, the Facebook page is a good relay on which we also think we can rely. COUTANCES WISHES TO ENTER THE DIGITAL ERA & THE SIMPLIFICATION OF ONLINE ACTIONSRather than redoing a website "only", it is the entire service offer to the citizen that we must review and digital technology can be useful to us. The website will now be seen as the single entry point to obtain: o Municipal information: council reports, publications o Economic, cultural, sporting information o Photo content via a shared photo library o Access to the digitized archives of the City of Coutances (ultimately, in approximately 3 years) o Downloading the local information distribution app via the service provider Citykomio Single access for a set of services such as: Territorial wifi The family portal Civil status and tax servicesvia FranceConnectCENTRALIZE, CONCENTRATE TO SIMPLIFYNot only do we have supports and services to create but above all, to take the user experience into account, we must create bridges, invisible to the citizen, in order to communicate all of these services and make access to information fluid. This is the whole issue of “e-coutances”.
|
Smarter Europe / Information and communication technology / Access to public sector information (including open data e-Culture, digital libraries, e-Content and e-Tourism)
| 7research_infrastructure
|
gen_8918e66eddd4ed06fa371348dd494735
|
FEDER - ENSICAEN - CPER MAT.CHEMIE - FEDERIM
|
Kohesio
|
ECOLE NATIONALE SUPERIEURE INGENIEURS
|
https://linkedopendata.eu/entity/Q3680341
|
Not available
|
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 7research_infrastructure
|
gen_34143d0f4c4ec3703b5dd323315cbd3c
|
Advancing open access
|
Arcadia Fundation
|
New York Public Library
|
360G-ArcadiaFund-3828
|
To further open access to scholarly and cultural materials
|
Other / Strategic
| 7research_infrastructure
|
gen_524551b4da3ae7d112017e5538ba0cf0
|
Advancing open access
|
Arcadia Fundation
|
University of California, Berkeley
|
360G-ArcadiaFund-4723
|
To build responsible access workflows for copyright and information policy. This grant ensures that Berkeley can continue helping scholars to use, create, and publish scholarship in ways that promote dissemination, accessibility, and impact.
|
Other / Strategic
| 7research_infrastructure
|
gen_db9c13dda167234a8a955f2a6277d4e1
|
Open Library of Humanities & Janeway
|
Arcadia Fundation
|
Birkbeck, University of London
|
360G-ArcadiaFund-4538
|
To strengthen open access to scholarly work in the humanities disciplines, allowing everyone the freedom to access academic research.
|
Other / Strategic
| 7research_infrastructure
|
gen_a3e4385c09319ece2eae454b70272353
|
Universal Library Project
|
Arcadia Fundation
|
Ithaka Harbors Inc
|
360G-ArcadiaFund-2537
|
To research the feasibility of developing a universal digital library.
|
Other / Strategic
| 7research_infrastructure
|
gen_788787866fda6bbb7db51c2f1e8457c5
|
Digitizing the Arthur and Janet Freeman Biblioteca Fictiva Collection
|
Arcadia Fundation
|
Johns Hopkins University
|
360G-ArcadiaFund-4827
|
To digitize and make publicly accessible items from the Arthur and Janet Freeman Bibliotheca Fictiva Collection of rare books and manuscripts on the history of forgery.
|
Discretionary / Discretionary
| 7research_infrastructure
|
gen_7c96d466164c7035d008dbc9753c3b91
|
A framework to make more books freely available online
|
Arcadia Fundation
|
New York Public Library
|
360G-ArcadiaFund-3961
|
To develop technology, policies, and partnerships that will increase the amount of book content that researchers can access digitally.
|
Books / Strategic
| 7research_infrastructure
|
gen_c06a41a34a620854d5dba412983de5b2
|
Digital Public Library of America
|
Arcadia Fundation
|
Digital Public Library of America
|
360G-ArcadiaFund-3174
|
To develop a working prototype of the Digital Public Library of America platform.
|
Other / Strategic
| 7research_infrastructure
|
gen_992b4b660a8d4ba26ac3e861962f36d4
|
Advancing open access
|
Arcadia Fundation
|
University of California Los Angeles
|
360G-ArcadiaFund-3658
|
To further open access to scholarly and cultural materials
|
Other / Strategic
| 7research_infrastructure
|
gen_17d97099b700fb6465e41bea1bb873ee
|
Advancing Open Access at UCLA
|
Arcadia Fundation
|
UCLA Library
|
360G-ArcadiaFund-4257
|
The Library plans to put this generous contribution to good use by funding the publication of open access monographs via TOME, and to further open access initiatives by membership and participation in organizations such as Libraria.
|
Other / Strategic
| 7research_infrastructure
|
gen_52574e7b0e17af31763613b01a6bbfd5
|
Health and Demographic Surveillance System
|
Medical Research Council
|
London School of Hygiene and Tropical Medicine
|
HRCS22_01350
|
The Unit maintains three Health and Demographic Surveillance Systems in Basse, Farafenni, and West Kiang. The HDSS collects data on vital events, namely births, deaths, migrations, pregnancy, educational level, ethnicity, vaccination status, socio economic status and cause of death (through Verbal Autopsies) using the electronic data capture (EDC) method via RedCap application. We aim to provide baseline data, sampling frame and identify clinical cases/study subjects to scientists for community-based research. We also provide a denominator for estimating impact studies, generate longitudinal information on the health of the population and provide quantitative evidence for scientific investigations as well as monitor demographic and mortality trends in populations.
|
2.4 Surveillance and distribution / Unit
| 7research_infrastructure
|
gen_e37866562423dd7d0cb619eb8f6fb0b7
|
Re-Mix: Design Workshops for Accessible, Usable, and Inclusive Environmental Data Sets
|
Wellcome Trust
|
Open Environmental Data Project
|
HRCS22_12442
|
No abstract available for this analysis.
|
No Research Activity assigned
| 7research_infrastructure
|
gen_e86b367abe7fcb3f408744f6a0c9ecff
|
Transparent Peer Review for Open Science and Research Assessment
|
Wellcome Trust
|
European Molecular Biology Organization
|
HRCS22_13833
|
A scaleable, interoperable mechanism to establish transparent peer review in scientific journals and preprints as a standard optimized for the browsing, interpretation and assessment of research papers and preprints. The proposed tools and standards will allow inclusion of peer review formally in research assessment by funders and research institutions.
|
No Research Activity assigned
| 7research_infrastructure
|
gen_8c5e06fd4df1aee454607c2da5f68582
|
AGATA: Precision Spectroscopy of Exotic Nuclei
|
Science and Technology Facilities Council
|
University of York
|
HRCS22_22488
|
The structure of the atomic nuclei, i.e. how protons and neutrons arrange themselves and how they interact among each other to form complex nuclei, has a decisive impact on everyday life, from the very existence of carbon-based life on Earth to critical nuclear physics applications such as carbon dating. Our understanding of nuclear structure is still elusive and relies on sophisticated experiments that deliver critical observables of atomic nuclei. For example, our experiments use particle accelerators that collide nuclei travelling at up to 50% the speed of light on stationary material to induce nuclear reactions. Typically, fewer than one in a million reactions will create the nucleus under study and the states of interest live, typically for less than a billionth of a second. To detect such rare events and measure the properties we are after, we need to develop very sensitive instruments. This project supports the development of one of the most sensitive "microscopes", the AGATA spectrometer, for gamma rays that are emitted during the accelerator-induced nuclear reactions. These gamma rays carry critical information about what happened during the (violent) nuclear reaction. By studying the energy and direction of the gamma rays, we can extract the properties of the atomic nuclei that were involved in the collisions. Our results will help address critical questions in modern nuclear science. AGATA constitutes a dramatic advance in gamma-ray detection that has wide ranging applications in medical imaging, astrophysics, nuclear safeguards and radioactive-waste monitoring, as well as introducing new detection capability for nuclear-structure studies. Indeed, the instrumentation and technical advances driven by this work and the knowledge gained by those involved will be important in a wide range of applications, such as in medicine and industry. For example, in medical imaging, reconstruction of the gamma-ray energies and determination of their direction will result in vastly improved images. Another beneficiary will be in nuclear safeguards where one of the big problems is the identification of the range of isotopes in waste and the determination of their quantities.
|
Missing/Incomplete
| 7research_infrastructure
|
gen_d84f164e5278571636786e0c88241991
|
Gates Foundatoin
|
Harvard University
|
INV-016892
|
to support state capacity for collecting and analyzing data to support decision making
|
Global Health and Development Public Awareness and Analysis / U.S. Program
| 7research_infrastructure
|
|
gen_6ea954a358ce3a7322ca5292fe89c069
|
Graphene Flagship 2D Experimental Pilot Line
|
European Commission
|
Airbus Defence and Space; AVANZARE INNOVACION TECNOLOGICA SL; NAWATECHNOLOGIES; Imec; Delft University of Technology; Technion - Israel Institute of Technology; Università di Pisa; BEDIMENSIONAL SPA
|
CORDIS-952792
|
The 2D Experimental Pilot Line (2D-EPL) project will establish a European ecosystem for prototype production of Graphene and Related Materials (GRM) based electronics, photonics and sensors. The project will cover the whole value chain including tool manufacturers, chemical and material providers and pilot lines to offer prototyping services to companies, research centers and academics. The 2D-EPL targets to the adoption of GRM integration by commercial semiconductor foundries and integrated device manufacturers through technology transfer and licensing. The project is built on two pillars. In Pillar 1, the 2D-EPL will offer prototyping services for 150 and 200 mm wafers, based on the current state of the art graphene device manufacturing and integration techniques. This will ensure external users and customers are served by the 2D-EPL early in the project and guarantees the inclusion of their input in the development of the final processes by providing the specifications on required device layouts, materials and device performances. In Pillar 2, the consortium will develop a fully automated process flow on 200 and 300 mm wafers, including the growth and vacuum transfer of single crystalline graphene and TMDCs. The knowledge gained in Pillar 2 will be transferred to Pillar 1 to continuously improve the baseline process provided by the 2D-EPL. To ensure sustainability of the 2D-EPL service after the project duration, integration with EUROPRACTICE consortium will be prepared. It provides for the European actors a platform to develop smart integrated systems, from advanced prototype design to small volume production. In addition, for the efficiency of the industrial exploitation, an Industrial Advisory Board consisting mainly of leading European semiconductor manufacturers and foundries will closely track and advise the progress of the 2D-EPL. This approach will enable European players to take the lead in this emerging field of technology.
|
H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET)
| 3networking_collaborative
|
gen_ca4d06d4aa6040f5ea34a0636ab0995f
|
JEOL 2100PLUS(CR)
|
NIH
|
UNIVERSITY OF GEORGIA
|
1S10OD034282-01
|
Project Summary/Abstract Cryogenic Transmission Electron Microscopy (cryoTEM) has emerged as a powerful approach to acquiring structural information from proteins, subcellular organelles, and other biomacromolecules and their assemblies. This proposal seeks funding to bring cryoTEM capabilities to the University of Georgia for the purpose of facilitating NIH-supported research related to cell organelle biogenesis, the biochemistry of metabolism and gene expression, the mechanisms of diverse human diseases and disorders, antibody therapeutics, antivirals, treatments for infectious diseases, and fundamental structural and cellular biology. The proposed equipment includes a cryo-capable, 200 kV transmission electron microscope (JEOL 2100PLUS) with a direct electron detection device (Direct Electron DE16ER camera) and the essential equipment needed for sample vitrification and handling (a Leica EM GP2 automatic plunge freezer, and a Gatan Elsa cryo sample holder with turbo benchtop pumping station). This multipurpose cryoTEM system will support the needs of NIH-funded investigators at the University of Georgia (UGA) for (1) the preparation and screening of vitrified samples; (2) data collection for single particle analysis, tomographic reconstructions, and micro-electron diffraction; and (3) improved conventional TEM imaging. This equipment will be installed at the Georgia Electron Microscopy (GEM) core facility in custom-designed laboratory space, and it will be operated and maintained by GEM’s staff. By establishing campus-level access to cryoTEM instrumentation, services, expertise, and hands-on training, this project will enable numerous biomedical researchers to incorporate cryoTEM methods into their research programs. UGA’s vibrant, NIH-supported research groups include five major users of cryoTEM, eight minor users of cryoTEM, and additional investigators who will be future cryoTEM practitioners. Project Narrative Cryo-transmission electron microscopy has emerged as a powerful technique for acquiring key structural information from proteins, subcellular organelles, and other biomacromolecules and their assemblies. This proposal seeks funding to bring cryo-electron microscopy capabilities to the University of Georgia for the purpose of facilitating NIH-supported research progress by producing new knowledge related to cell organelle biogenesis, the biochemistry of metabolism and gene expression, and the mechanisms of diverse human diseases and disorders. These projects have strong relationships to public health priorities, specifically by developing targets relevant to respiratory diseases (e.g., RSV, hMPV, influenza), infectious diseases (e.g., malaria, H. pylori), and neurodegenerative processes (e.g., Parkinson’s and Alzheimer’s diseases) through structure-based drug and vaccine candidate design.
|
Other Research-Related
| 7research_infrastructure
|
gen_50c67c4d5105eefe49fcb6b60f9eeb41
|
TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) INFORMATICS RESEARCH CENTER (IRC)
|
NIH
|
UNIVERSITY OF MICHIGAN AT ANN ARBOR
|
268201800002I-0-759202300001-1
|
NHLBI's Trans-Omics for Precision Medicine (TOPMed) program started in 2014 as the flagship program supporting the development of precision medicine for heart, lung, blood diseases and sleep disorders. The main goal is to generate a large volume of genomics data that have sufficient statistical power for scientific discovery. The data are generated and processed first in TOPMed before being uploaded to external databases, database of Genotypes and Phenotypes (dbGaP) and BioData Catalyst (BDC) for researchers to access. In 2016, under TOPMed program, NHLBI funded nine (9) Centralized Omics Resource (CORE) centers that have generated approximately 200,000 whole genome sequencing and multi-omics data. As TOPMed enters its next phase TOPMed2.0 focusing on functional genomics and disease mechanism, the CORE needs to be upgraded to CORE 2.0 generating more functional genomics data, including omics data at single-cell resolution. CORE 2.0 needs to generate a large volume of functional genomics data and is in need of contractors that can provide a high capability of generating omics data.
|
R and D Contracts
| 7research_infrastructure
|
gen_adbc44fe348d8e63998d31885f1bd98a
|
i-AKC: Integrated AIRR Knowledge Commons
|
NIH
|
UT SOUTHWESTERN MEDICAL CENTER
|
5U24AI177622-02
|
PROJECT SUMMARY/ABSTRACT: Immune receptors of the adaptive immune system (antibody/B-cell or T-cell receptors, or AIRR data) are designed to recognize and remove pathogens, and also recognize and preserve self-molecules. Therefore, these receptors have to be highly variable; it has been estimated that the number of possible human B-cell receptors approaches 1013. In addition to the diversity of these receptor sequences, the genes that underlie the production of these receptor molecules are highly diverse and complicated, and the data describing how these receptors bind to antigens (such as influenza) are also highly complex. Repositories to curate, analyze, and share these data are necessary to characterize B/T cell function in disease, as well as facilitate the discovery of new vaccine leads and therapeutic monoclonal antibodies to suppress autoimmune disease and cancer. Such data repositories are available, but they tend to focus on only one aspect of the data. Given that these repositories typically have been developed independently, the primary data and associated metadata (age, demography, sex, etc.) of the samples are stored in non-compatible forms, and in addition, the enormous size and complexity of the data make data sharing and integrated analyses extremely challenging. The goal of the proposed research is to establish the integrated AIRR Knowledge Commons (i-AKC), a novel knowledgebase that will allow seamless access, exploration, analysis, querying, and downloading of these various data types from a single point of entry. Our approach will be based on the very successful AIRR Community initiative, a group of immunologists, bioinformaticians, and experts in ethics and data sharing who have worked together since 2015 to develop protocols and standards for analysis and data sharing tools. One of the outcomes of the AIRR Community is the AIRR Data Commons, a set of data repositories that store the immense immune receptor repertoires that underlie the adaptive immune response. The proposed research takes the next important step of integrating (1) the AIRR Data Commons with repositories of (2) antigen/receptor binding and (3) germline immune genes. Steps to producing the i-AKC are (1) develop a common data model and establish common data elements relying on existing ontologies and community standards, (2) integrate the data using innovative algorithms and automation tools and enrich it with new knowledge derived from algorithms operating on the integrated data, and (3) community building. Using the i-AKC, researchers will, for example, be able to discover receptor sequences based on metadata or sequence searches, seamlessly examine information on the germline genes underlying these receptor sequences or examine what is known about the binding targets of these receptors. This novel and innovative knowledgebase will facilitate data and knowledge exploration that would be prohibitively difficult using sets of “siloed” repositories and will greatly accelerate biomedical research in autoimmune disease, infectious disease, transplantation, and cancer and directly improve patient care. PROJECT NARRATIVE The adaptive immune response is shaped by a constellation of factors including genetics, immune preparedness, and antigen exposure that can protect us from or predispose or drive us to illness. While isolated data repositories exist that cover each of these factors, the proposed work will harmonize, integrate, and enhance those resources to enable a holistic understanding of adaptive immune responses. The systems-level analysis made possible by this knowledge integration will improve public health by accelerating the use of adaptive immune repertoire data to develop new therapeutics, diagnostics, and patient monitoring.
|
Other Research-Related
| 7research_infrastructure
|
gen_f869befa43d0cb711400f04ce4581493
|
Metabolism Core
|
NIH
|
WASHINGTON UNIVERSITY
|
5U54DK137332-02
|
Project Summary/Abstract: Metabolism Core The Metabolism Core (Meta-Core) is a Biomedical Resource Core within the Washington University Chronic Kidney Disease National Resource Center. Chronically injured kidneys have altered metabolism, and recent data suggests that these metabolic changes play a causative role in progressive decline in kidney function. The ability to interrogate metabolism is crucial to understanding chronic kidney disease pathophysiology, but there are a number of barriers for kidney researchers to do so. First, many investigators interested in chronic kidney disease do not have expertise in metabolism and metabolic assays. Second, many of these assays require expensive equipment not readily available to many labs. To address these issues, the Meta-Core faculty consisting of Leslie Gewin, M.D., Core Director, Brian Finck, Ph.D., Associate Core Director, Gary Patti, Ph.D., Core Collaborator, and Leah Shriver, Ph.D., Core Collaborator, will perform consultations with Meta- Core users to guide and design the best metabolic assay to answer the research question. Several assays will be available to the Meta-Core users to interrogate metabolism at the cellular or whole kidney level. These assays include Seahorse bioflux analyses with the use of primary cells or freshly isolated tubules ex vivo, both more representative of the highly oxidative proximal tubules than commercially available primary human tubule cells or conditionally immortalized tubule cells. We can measure oxidation of fatty acids or glucose/pyruvate in kidney tissue ex vivo using radioactive substrate oxidation assays. The 3H-palmitate assay, not often performed on kidney tissue, has advantages over the more commonly used 14C-palmitate assay as it detects complete oxidation of long chain fatty acids through the electron transport chain and is easier to perform (collect 3H2O rather than 14CO2). We can also refer users to the Nutrition Obesity Research Center’s high- resolution respirometer (Oroboros Oxygraph 2k) to detect respiration in isolated mitochondria. In addition, untargeted metabolomics and stable isotope tracer studies will be performed on primary cells in vitro and in vivo. The Meta-Core faculty are all committed to sharing validated protocols and methods with the O’Brien Consortium as well as larger scientific community. In addition, we will help train the kidney scientific community how to generate primary proximal tubule cells and tubules and use the Seahorse bioflux analysis in a way that yields consistent, reproducible results. In particular, the importance of validating cell number to use, post- analysis correction for number of cells, and proper concentrations of reagents will be emphasized. The Meta- Core will leverage the expertise and equipment of other Cores at Washington University to produce complementary services for a reduced rate.
|
Research Centers
| 7research_infrastructure
|
gen_48f9a15bb810a0503a8629dc3e20e585
|
FEDER - IFPC - Cidricole Station Renovation
|
Kohesio
|
ORGPRO - INSTITUT FRANCAIS DES PRODUCTIONS CIDRICOLES
|
https://linkedopendata.eu/entity/Q3680250
|
Built in 1987, the IFPC cider station initially accommodated 2 employees. A first extension was carried out around 1995. Today, the IFPC can accommodate up to 10 employees and trainees but the organization of the building and the agricultural sheds are no longer adapted to the needs of the activities and reception. After 30 years, renovations and upgrading are necessary.
|
Smarter Europe / Research and innovation / Research and innovation activities in private research centres including networking
| 7research_infrastructure
|
gen_85965ccbc1f028f267b73c44da88ffb6
|
Implementation of the Ornais phase 1 digital plan - FEDER request
|
Kohesio
|
DEPARTEMENT DE L ORNE
|
https://linkedopendata.eu/entity/Q3673366
|
This project is carried out by the Department of Orne. The public actions included in the Ornais Digital Plan (PNO) aim to achieve a homogeneous treatment of the Orne territory allowing in the long term a generalized THD service to the department via the action of the Department, in addition to the operations carried out by private operators on the perimeter of the approved municipalities. The Department of Orne validated the PNO on March 22, 2013. The implementation of the first stage of the first phase, in the form of contracts works, was voted on September 27 and October 25, 2013. These first works contracts relate to the optical service of strategic sites. The work is carried out under project management and departmental project management. The municipalities or EPCI will be asked to provide financial participation. The action of the Department of Orne is concentrated only outside areas of private initiative, and in a search for maximum use of existing infrastructure, in order not to duplicate private networks. FttO The Department has chosen to connect by optical fiber the 33 ZA and 22 priority strategic public sites ineligible for an Orange FttO wholesale offer (CE2O type) on August 1 2014. The estimated total cost of connecting these 55 sites is 6.7 M excluding VAT.FttH The Department has chosen to deploy, in phase 1, the plates of the communities of communes (Cdc) of the Pays d'Argentan (former perimeter) and the Pays de L'Aigle and de la Marche, (in its 2013 administrative perimeter), because they meet the following criteria: - Plates complementary to private initiative; - Clear administrative division (EPCI of the 3rd and 4th commune of Orne); - Cost per catch among the lowest in Orne (around 700 for the Cdc of the Pays d'Argentan and 1,300 for the Cdc of the Pays de L'Aigle and de la Marche); - Plates of approximately 10,000 shots. The Pays d'Argentan Cdc brings together 9,909 outlets spread over 12 municipalities, including 8,000 in Argentan. The Cdc des Pays de L'Aigle et de la Marche brings together 12,456 outlets spread over 25 municipalities, including 5,300 in L'Aigle. The total estimated cost for these 2 public FttH plates is 23.4 M excluding tax, excluding final connection. The Department of Orne will be able to develop the FttH plates selected, depending on the appetite of Orne communities for an FttH deployment, as well as depending on the results of engineering studies. In the 2nd phase of the project, public FttH deployments will continue to achieve population coverage of 75% by 2030.
|
Smarter Europe / Information and communication technology / ICT: Very high-speed broadband network (access/local loop; >/= 100 Mbps)
| 7research_infrastructure
|
gen_9f5774ee1b1ed079121430c281147aa5
|
Effect of Electroacupuncture in Patients With Irritable Bowel Syndrome
|
National Institutes of Health (NIH)
|
Chinese University of Hong Kong
|
NCT00900965
|
Irritable bowel syndrome (IBS) is the most common digestive disorder that affects more than
5% of population in Hong Kong. However, there is no effective treatment of IBS using Western
Medicine. Acupuncture, a traditional therapeutic modality, has been used in China for
thousands of years for various pain disorders. In addition to analgesia, acupuncture has also
been shown to influence physiology of gastrointestinal tract. The investigators set out to
evaluate the therapeutic value of acupuncture in IBS. The investigators will study its
effects on rectal sensation and brain activity in patients with IBS.
All patients will be evaluated for study eligibility at visit 1 (baseline). Baseline
assessment includes individual IBS symptoms (pain/discomfort, bloating, constipation, and
diarrhea) as perceived by patients will be scored. The syndrome of IBS patients will also be
recorded and analyzed based on the Chinese medicine theories. All patients will then undergo
baseline rectal barostat for thresholds of rectal sensation. At visit 2, eligible patients
will be randomly assigned to either (1) electroacupuncture or (2) sham electroacupuncture
treatment groups. Functional Magnetic Resonance Imaging (fMRI) scanning will be performed
before, during and after the electroacupuncture or sham electroacupuncture treatment.
|
Device
| 4other_research_funding
|
gen_2d6bdbd5b080ec6515ec30903ce4ad99
|
Pharmacodynamic Study on Efficacy of Clopidogrel With St. John's Wort
|
Louise von Hess Medical Research Institute
|
Lancaster General Research Institute
|
NCT01330589
|
The purpose of this study is to evaluate whether patients post PCI receiving clopidogrel who
are carriers of at least one CYP 2C19 loss-of-function allele may achieve improved
pharmacodynamic efficacy of clopidogrel when treated with the CYP 2C19 enzyme inducing agent,
St. John's wort, as compared with placebo.
Hypothesis
1. Reduced platelet reactivity is present in patients receiving St. John's wort as compared
to placebo when utilized in combination with clopidogrel
2. The combination or St. John's wort and clopidogrel results in enhanced platelet
inhibition
|
Drug
| 4other_research_funding
|
gen_1777bed998dc097d0c38fc2a77be56b8
|
SMARTease Trial: Evaluating Stroke Help Distance Interventions to Improve Cognitive Performance Post-Stroke
|
Canadian Institutes of Health Research (CIHR)
|
Capital District Health Authority, Nova Scotia, Canada
|
NCT01407081
|
The purpose of this study is to provide evidence for the feasibility and initial
effectiveness of a manualized, telephone-based (telehealth) approach to the delivery of
cognitive interventions (SMARTease) targeted to improve cognitive performance in daily
activities after stroke.
|
Behavioral
| 4other_research_funding
|
gen_eca44e32b972bb8e25763a835e669e6f
|
Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer
|
National Cancer Institute (NCI)
|
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
|
NCT00049504
|
This phase II trial studies how well giving fludarabine phosphate, cyclophosphamide,
tacrolimus, mycophenolate mofetil and total-body irradiation together with a donor bone
marrow transplant works in treating patients with high-risk hematologic cancer. Giving low
doses of chemotherapy, such as fludarabine phosphate and cyclophosphamide, and total-body
irradiation before a donor bone marrow transplant helps stop the growth of cancer cells by
stopping them from dividing or killing them. Giving cyclophosphamide after transplant may
also stop the patient's immune system from rejecting the donor's bone marrow stem cells. The
donated stem cells may replace the patient's immune system cells and help destroy any
remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a
donor can also make an immune response against the body's normal cells. Giving tacrolimus and
mycophenolate mofetil after the transplant may stop this from happening
|
Radiation
| 4other_research_funding
|
gen_02c592f16c6c7e8ffca0674c18adbdf5
|
Phase III Radium 223 mCRPC-PEACE III
|
UNICANCER
|
Cliniques Universitaires de Saint Luc
|
NCT02194842
|
The objective of this randomized phase III open label trial is to assess if upfront
combination of enzalutamide and Ra223 improves radiological progression-free survival
compared to enzalutamide single agent in asymptomatic or mildly symptomatic castration
resistant prostate cancer patients metastatic to bone.
|
Drug
| 4other_research_funding
|
gen_e81c637e200a2d0ee38264485d4502ff
|
Pre-operative Immunotherapy Combination Strategies in Breast Cancer
|
Asan Medical Center
|
Queen Mary University of London
|
NCT03395899
|
International, open label, window of opportunity phase II trial that aims to evaluate the
effects of immunotherapy based treatment combinations in women with untreated, histologically
confirmed, operable, ER+, HER2-negative breast cancer.
|
Drug
| 4other_research_funding
|
gen_66a80fd86440e53d09c3117e65eb67a5
|
U of A/ U of M Beans and Peas Health Claim Project
|
Alberta Innovates Health Solutions
|
University of Manitoba
|
NCT01661543
|
The purpose of this study is to compare how regularly eating (dried) beans or peas or rice
(control) lowers blood lipids, particularly Low Density Lipoprotein cholesterol and total
cholesterol, in mildly hypercholesterolemic men and women. The investigators hypothesize that
regularly eating beans or peas will significantly improve blood lipid profiles in these
people.
Participants in this study will consume 1 study food item 5 out of 7 days a week containing
beans or peas or rice for a total of 6 weeks. This study will benefit Canadian pulse growers
by enhancing development of food products for human consumption and supporting marketing
strategies to increase awareness that a diet rich in pulses can improve human health.
Measuring changes in blood and urinary polyphenol levels will help to verify whether these
compounds play a role in the beneficial actions of beans and peas and subsequently assist
with the identification of the beneficial bean/pea components. This in turn, will enable crop
breeders to select for plants that are rich in these compounds.
|
Dietary Supplement
| 4other_research_funding
|
gen_d353e4dedbe42169d03c96a55aca5aae
|
Study of the Combination of Anecortave Acetate and Triamcinolone Acetonide for the Treatment of Exudative Age-Related Macular Degeneration (AMD)
|
Alcon Research
|
Manhattan Eye, Ear & Throat Hospital
|
NCT00211419
|
The purpose of this study is to evaluate the safety of combining juxtasclerally administered
anecortave acetate 15 mg with triamcinolone acetate 4 mg administered intravitreally
following photodynamic therapy with verteporfin for the treatment of exudative age-related
macular degeneration (AMD).
|
Drug
| 4other_research_funding
|
gen_b979413e3f51bf8840313d4794d9e103
|
Pharmacokinetic Study of Aprepitant in BEP Treatment of Patients With Testis Carcinoma (A-BEP)
|
Merck Sharp & Dohme Corp.
|
Radboud University (RUNMC)
|
NCT00429754
|
The purpose of the study is to investigate whether there is an interaction occurs between
etoposide and aprepitant in patients with testis carcinoma treated with the standard BEP
regimen.
Also to determine how long treatment with aprepitant is necessary in BEP regimen for 5
consecutive days.
|
Drug
| 4other_research_funding
|
gen_a09e7a29691ef9acaec07b97638d0393
|
A Randomized Study of Intraperitoneal tgDCC-E1 and Intravenous Paclitaxel in Women With Platinum-Resistant Ovarian Cancer
|
National Cancer Institute (NCI)
|
UT MD Anderson Cancer Center
|
NCT02157870
|
Multi-Phase study (I/II) that did not progress to Phase II of clinical trial, terminated
early due to low accrual, separate ClinicalTrials.gov Registration NCT00102622 for Phase I of
study:
Phase I:
- Enrollment of up to 24 subjects in 8 cohorts of three subjects to one of three
combinations of intraperitoneal (IP) tgDCC-E1A + intravenous (IV) paclitaxel by the
continuous reassessment method (CRM) will be sufficient to establish the MTD
- The single agent paclitaxel cohort will consist of 24 subjects
Phase II:
- Enrollment of up to 20 subjects to one of three combinations of IP tgDCC-E1A + IV
paclitaxel decided by Phase I.
- The single-agent paclitaxel cohort will consist of 20 subjects.
|
Drug
| 4other_research_funding
|
gen_682e84d0c51f40a44647076dfb9e3a1f
|
Trial of Bevacizumab and Ixabepilone for Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)
|
Genentech, Inc.
|
Providence Health & Services
|
NCT01057212
|
This is a non-randomized, open-label, single arm phase II trial of the combination of
bevacizumab and ixabepilone in patients with advanced- or metastatic non-squamous NSCLC
progressive after first or second-line therapy. The main objective is to evaluate the
progression-free survival in patients with advanced or metastatic non-squamous NSCLC being
treated with ixabepilone and bevacizumab.
|
Drug
| 4other_research_funding
|
gen_6d77c577cd3f817b862c33948f7a5b0a
|
Parenting for Lifelong Health (PLH) - Masayang Pamilya (MaPa) Evaluation Study
|
Philippine Department of Social Welfare and Development
|
University of Oxford
|
NCT03205449
|
Parenting for Lifelong Health (PLH) Philippines Evaluation Study: Multisite randomised
controlled trial to compare the efficacy of a culturally-adapted parenting programme,
Masayang Pamilya, versus services as usual in the reduction of child maltreatment and
improvement of child wellbeing in low-income Filipino families with children aged two to six
years in Metro Manila (N = 120).
A previous study focused on adaptation and feasibility testing was conducted from January
2016 to February 2017. Community-based participatory approaches were used to culturally adapt
the Sinovuyo programme to a Filipino context. A formative evaluation using qualitative
in-depth interviews and focus group discussions with parents, as well as consultative
workshops with service providers and other stakeholders, examined issues regarding the needs
and concerns of Filipino parents, appropriateness of intervention components and delivery,
and other specific cultural issues in order to balance "fidelity" to evidence-based practices
with "fit" to the local context [11]. The Sinovuyo programme was then adapted into the MaPa
programme with local materials and approaches developed to fit the Philippine cultural
context based on findings from the formative evaluation.
|
Behavioral
| 4other_research_funding
|
gen_cb1ec3fc702d4b498f85d10e4434646f
|
HIV Vaccine Trial in Thai Adults
|
Henry M. Jackson Foundation for the Advancement of Military Medicine
|
Ministry of Health, Thailand
|
NCT00223080
|
The purpose of this study is to determine whether immunizations with an integrated
combination of ALVAC-HIV (vCP1521) boosted by AIDSVAX gp120 B/E prevent HIV infection in
healthy Thai volunteers.
|
Biological
| 4other_research_funding
|
gen_d9238fdf7ef2cddb4e8d32c0427ea5b8
|
Safety and Efficacy of Natalizumab in Combination With Avonex in the Treatment of Multiple Sclerosis
|
Elan Pharmaceuticals
|
Biogen
|
NCT00030966
|
The purpose of this study is to determine if natalizumab in combination with AVONEX is safe
and effective in delaying progression of individuals diagnosed with relapsing remitting
Multiple Sclerosis (MS).
|
Drug
| 4other_research_funding
|
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